Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders.

Abstract:

:Recent findings document numerous interactions between neuronal and glial systems that likely play a role in the pathophysiology of depression. These findings suggest that glia-derived neurotrophic protein S100B may play a significant role in developing depression. To test the relationship between S100B and depressive symptoms we designed cross-sectional clinical study including S100B serum and CSF levels in neurological patients with non-inflammatory disorders (NIND), who undergone cerebrospinal fluid assessment for diagnostic purposes. The present study was focused on psychometric testing of depression (BDI-II), anxiety (SAS) and alexithymia (TAS-20), and neurochemical measure of cerebrospinal fluid (CSF) and serum levels of S100B in 40 NIND inpatients [mean age 41.67]. The main result shows that S100B in CSF is significantly negatively correlated with BDI-II (Spearman R=-0.51, p<0.0009) but not with SAS and TAS-20. The finding indicates that decreased level of S100B in CSF is related to increased symptoms of depression in the NIND patients.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Uher T,Bob P

doi

10.1016/j.neulet.2012.09.003

subject

Has Abstract

pub_date

2012-11-07 00:00:00

pages

139-43

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)01197-4

journal_volume

529

pub_type

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