Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin.

Abstract:

:Activation of the complement system is believed to be involved in degenerative processes of certain neurological diseases, including Alzheimer disease. Recent data have shown that the mRNAs for these proteins can be detected in brain-derived mRNA. In this study, C4 mRNA was detected by polymerase chain reaction (PCR) amplification of mRNA from the human neuroblastoma cell lines IMR32, SK-SH and SK-MC, and the human astrocytoma cell line U373MG, while C3 expression was detected in SK-MC, SK-SH and U373MG cells. The SK-MC and U373MG cells expressed mRNA for C9. The mRNA for C1qB could not be detected in any of these cell lines.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Walker DG,McGeer PL

doi

10.1016/0304-3940(93)90652-2

subject

Has Abstract

pub_date

1993-07-09 00:00:00

pages

99-102

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90652-2

journal_volume

157

pub_type

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