Abstract:
:Activation of the complement system is believed to be involved in degenerative processes of certain neurological diseases, including Alzheimer disease. Recent data have shown that the mRNAs for these proteins can be detected in brain-derived mRNA. In this study, C4 mRNA was detected by polymerase chain reaction (PCR) amplification of mRNA from the human neuroblastoma cell lines IMR32, SK-SH and SK-MC, and the human astrocytoma cell line U373MG, while C3 expression was detected in SK-MC, SK-SH and U373MG cells. The SK-MC and U373MG cells expressed mRNA for C9. The mRNA for C1qB could not be detected in any of these cell lines.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Walker DG,McGeer PLdoi
10.1016/0304-3940(93)90652-2subject
Has Abstractpub_date
1993-07-09 00:00:00pages
99-102issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90652-2journal_volume
157pub_type
杂志文章abstract::Neurotrophic factors maintain and modulate neuron function in adults. We tested the hypothesis that neurotrophic factors rapidly alter intracellular calcium concentrations, thereby affecting neuron excitability. The majority of rat nodose neurons express TrkA, TrkB and TrkC receptor after 1 day in culture. Addition of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01223-5
更新日期:2003-01-09 00:00:00
abstract::Tyrosine hydroxylase-like immunoreactive (TH-IR) neurons with morphological features of interneurons were found throughout the human cerebral cortex. Quantitative estimates in 14 different cytoarchitectonic areas revealed a specific regional distribution pattern, neurons being less dense in primary cortical areas and ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90464-2
更新日期:1987-10-05 00:00:00
abstract::The present study was designed to observe the effect of orphanin FQ (OFQ, also known as 'nociceptin'), a newly-discovered neuropeptide, on pain behavior and morphine analgesia evaluated by formalin test in rats. It was found that intracerebroventricular (i.c.v.) injection of 0.1 microg OFQ had no effect on formalin-in...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00704-0
更新日期:1997-10-10 00:00:00
abstract::Morphine analgesia measured by the tail withdrawal test was examined in rats that were either restrained or left free during testing. It was found that restraint potentiated morphine analgesia and decreased the latency of the peak analgesic effect. Methysergide, a serotonin antagonist, and valine, which prevents the i...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90040-5
更新日期:1984-02-24 00:00:00
abstract::A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes. Complement activation is one of the cardinal pathological features of the inflammation. Intensive AD association studies investigating polymorphisms in inflammatory-related genes have been recently perfor...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3940(02)01218-1
更新日期:2003-01-16 00:00:00
abstract::Muscle vibration does not affect post-synaptic excitability of the corresponding motoneuronal pool, the concurrent depression of the monosynaptic reflex resulting from a pre-motoneuronal block of Ia spindle afferents. Indeed (1) both homonymous and heteronymous soleus responses (to electrical stimulation of the poster...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00537-5
更新日期:1997-08-08 00:00:00
abstract::Using in situ hybridization histochemistry, we have demonstrated that 3 alpha subunit mRNAs of the GABAA receptor are present in different cell populations of the bovine cerebellum. While the alpha 1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the alpha 2 mRNA a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90193-6
更新日期:1989-11-20 00:00:00
abstract::Small intestinal motility was monitored in conscious rats chronically fitted with intraparietal electrodes, the third and fourth weeks after intraperitoneal administration of saline (controls) or N-(2-chloro-ethyl)-N-ethyl-2-bromobenzylamine (DSP-4, 50 mg/kg), a noradrenergic neurotoxin. Norepinephrine concentrations ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90205-4
更新日期:1988-08-01 00:00:00
abstract::In vivo electrochemical techniques were employed to demonstrate that repeated treatment with classical antipsychotic drugs reduced basal dopamine (DA) release in the striatum and nucleus accumbens, whereas repeated treatment with atypical antipsychotics decreased DA release only in accumbens. Administration of apomorp...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90633-1
更新日期:1987-07-22 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.04.064
更新日期:2011-05-06 00:00:00
abstract::To elucidate the metabolic process generating amyloid-beta protein (A beta) from beta-amyloid precursor protein (APP) in human brain, we partially purified secretory forms and carboxyl-terminal fragments (CTFs) of APP from the white matter of a Down's syndrome brain. We obtained secretory forms of APP which lack the e...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11307-i
更新日期:1995-02-17 00:00:00
abstract::The cellular prion protein (PrP(C)) is crucial for the development of transmissible spongiform encephalopathies (TSEs), where the pathogenic scrapie isoform (PrP(Sc)) of the same protein, is considered to be the principal or sole infectious agent. Here, we report findings on PrP(C) expression in the rat forebrain, usi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00563-7
更新日期:1999-09-03 00:00:00
abstract::Much research is focused on developing novel drugs to improve memory. In particular, psychostimulants have been shown to enhance memory and have a long history of safe use in humans. In prior work, we have shown that very low doses of amphetamine administered before training on a Pavlovian fear-conditioning task can d...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.10.049
更新日期:2010-01-01 00:00:00
abstract::In order to determine which types of neuron in laminae I-III of the rat spinal dorsal horn contain the peptide galanin, pre-embedding immunocytochemistry with antiserum to galanin was combined with post-embedding detection of GABA- and glycine-like immunoreactivities. Sixty-eight galanin immunoreactive neurons in lami...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11358-4
更新日期:1995-03-03 00:00:00
abstract::The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00402-3
更新日期:1997-06-13 00:00:00
abstract::We examined the specific rat 125I-alpha-rat atrial natriuretic peptide(1-28)[ANF-(99-126)] (125I-rANP) binding sites in the cerebral capillaries from the cerebral cortex of male adult Wistar rats. The binding of 125I-rANP at 37 degrees C was saturable and of high affinity with a Kd of approximately 100 pM and Bmax of ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90254-6
更新日期:1988-08-15 00:00:00
abstract::Retrograde axonal transport and fluorescent retrograde labelling of neurons were investigated in a crustacean motor system. A fluorescent tracer (Granular blue) was injected into an antennal muscle of rock lobster in order to identify the motor neurons innervating it. After an appropriate post-injection survival time,...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90001-1
更新日期:1985-04-09 00:00:00
abstract::In the presence of atropine electrical transmural stimulation (using repetitive volleys, e.g. 3 pulses at 50 Hz applied every 4 s) of full thickness longitudinal strips of guinea-pig ileum produced non-cholinergic excitatory junction potentials (EJPs) and inhibitory junction potentials (IJPs) in the circular muscle la...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90006-6
更新日期:1986-01-02 00:00:00
abstract::Tau is a neuronal microtubule-associated protein whose function is regulated by site-specific phosphorylation. One protein kinase that is likely to play an important role in regulating the phosphorylation state of tau in vivo is glycogen synthase kinase (GSK) 3beta. The activity of GSK3beta is regulated by specific pr...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.04.101
更新日期:2005-08-26 00:00:00
abstract::Presenilin-1 (PSEN1) mutations I143T and G384A give rise to severe early onset Alzheimers's disease in two extensively studied Belgian families, AD/A and AD/B. In this study we investigated the influence of the I143T and G384A mutations on PSEN1 proteolytic processing. Hereto we analyzed PSEN1 processing in lymphoblas...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00722-3
更新日期:1999-10-29 00:00:00
abstract::Tourette syndrome/chronic tic phenotype (TS-CTD) is a neurological disorder manifested particularly by motor and vocal tics and associated with a variety of behavioral abnormalities. Recently, the mitochondrial ribosomal protein L3 gene (MRPL3) S75N, the DnaJ (Hsp40) homolog subfamily C member 13 gene (DNAJC13) A2057S...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.03.097
更新日期:2012-05-23 00:00:00
abstract::Diabetic peripheral neuropathy (DPN) affects the sensory function of the hands and, consequently, may negatively impact hand dexterity, maximum grip strength (GSMax), and hand grip force (GF) control during object manipulation. The aims of this study were to examine and compare the GF control during a simple holding t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.08.071
更新日期:2017-10-17 00:00:00
abstract::Erythropoietin (EPO) has recently been shown to have a neuroprotective effect in animal models of traumatic brain injury (TBI). However, the precise mechanisms remain unclear. Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI. We, therefore, tried to analyze how reco...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.08.022
更新日期:2007-10-02 00:00:00
abstract::The effects of micro-electrophoretically applied melatonin on the electrical activity of Purkinje cells in the cerebellum of anaesthetized pigeons were studied. The proportion of excitatory and inhibitory responses to the pineal indoleamine varied significantly depending on whether the cells were tested during the day...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90072-8
更新日期:1986-12-12 00:00:00
abstract::This study aimed to determine the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on electroencephalograms (EEGs) of rats. Fifteen Sprague-Dawley rats were subject to 100 pulses of 0.5 Hz rTMS, or sham stimulation. EEGs were recorded before stimulation and within 1 min after rTMS or sham st...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.10.054
更新日期:2007-01-29 00:00:00
abstract::To demonstrate the preference of lactate over glucose as an energy substrate in normal brain tissue under normoxic condition, the dynamic changes in glucose uptake by lactate loading were investigated in living rat brain slices using a positron autoradiography technique. Fresh rat brain slices were incubated with [18F...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00413-3
更新日期:1998-06-19 00:00:00
abstract::Intrastriatal injections of kainic acid in rat brain, which destroyed striatal nerve cell bodies and their axons projecting to the substantia nigra (s. nigra) decreased the rate of breakdown of exogenuously added substance P by washed slice preparations of s. nigra. Injection of 6-hydroxydopamine (6-OHDA) into the s. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(79)96116-0
更新日期:1979-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to estimate the effect of altitude (1500m vs. 3200m) on balance strategies, and to determine the influence of age (> or <40 years) and expertise (> or <20days of mountain climbing/year) on postural stability at altitude. METHOD:Eighty-nine volunteer mountaineers were tested at 1500m, ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.06.010
更新日期:2017-09-14 00:00:00
abstract::In this paper, functional connectivity of steady-state visual evoked potential (SSVEP) was investigated. Directed transfer function (DTF) was applied to cortical signals recorded from electroencephalography (EEG) in order to obtain connectivity patterns. Flow gain was proposed to assess the role of the specific brain ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.05.061
更新日期:2011-07-25 00:00:00
abstract::It has been hypothesized that auditory temporal processing plays a major role in the aetiology of dyslexia. Event-related brain potentials (mismatch negativity, MMN) of auditory temporal processing were assessed in 15 dyslectic adults and 20 controls. A complex tonal pattern was used where the difference between stand...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00785-5
更新日期:1999-11-26 00:00:00