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Secretory cleavage of beta-amyloid precursor protein in the cerebral white matter produces amyloidogenic carboxyl-terminal fragments.

Abstract：

:To elucidate the metabolic process generating amyloid-beta protein (A beta) from beta-amyloid precursor protein (APP) in human brain, we partially purified secretory forms and carboxyl-terminal fragments (CTFs) of APP from the white matter of a Down's syndrome brain. We obtained secretory forms of APP which lack the entire A beta sequence and CTFs which contain the full-length A beta from the cerebral white matter. Some A beta-lacking secretory APP isoforms in the white matter were derived from APP695. These results suggest that amyloidogenic CTFs can be produced by secretory cleavage of APP which is anterogradely transported through the axon in human brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tokuda T,Tanaka K,Kametani F,Ikeda S,Yanagisawa N

doi

10.1016/0304-3940(95)11307-i

subject

Has Abstract

pub_date

1995-02-17 00:00:00

pages

149-52

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)11307-I

journal_volume

186

pub_type

杂志文章

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