Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations.

abstract：:Intracellular cyclic AMP regulation systems play an important role in the mechanisms of morphine dependence and withdrawal. In the present study, to clarify the involvement of phosphodiesterase (PDE) 4, degradation enzyme of cyclic AMP in morphine dependence and withdrawal we investigated the activities of PDE4 after ...

journal_title：Neuroscience letters

authors： Kimura M,Tokumura M,Itoh T,Inoue O,Abe K

更新日期：2006-08-14 00:00:00

abstract：:In order to assess functional skills of older adults, both timed up and go (TUG) test and gait speed (GS) test are well validated concerning their predictive capacities. However, the question remains unclear which one of these tests represents better the whole physical performance of older adults. The aim of this stud...

journal_title：Neuroscience letters

authors： Kubicki A

更新日期：2014-08-08 00:00:00

abstract：:Although cAMP response element binding protein (CREB)- and extracellular-regulated protein kinase (ERK)-mediated pathways have been linked to each other in neuronal differentiation, involvement of these in hippocampal neuronal cell line has not been defined. Using an immortalized hippocampal cell line, HiB5, we have t...

journal_title：Neuroscience letters

authors： Son H,Kim KO,Kim JS,Chang MY,Lee SH,Lee YS

更新日期：2001-07-27 00:00:00

abstract：:A Golgi-Cox, cresyl violet, and histofluorescence study has revealed the presence of dendrite bundles in nuclei raphe dorsalis (NRD) and centralis superior (NCS) in the rabbit brain stem. In NRD, bundles were found in the midline, traversing the medial longitudinal fasciculus (MLF) and in a circumferential location ar...

journal_title：Neuroscience letters

authors： Felten DL,Harrigan P

更新日期：1980-03-01 00:00:00

abstract：:The aim of the present study was to investigate the moderating effect of intolerance of uncertainty (IU) on exposure to aversion and its anticipation using event-related potentials (ERPs). Sixteen subjects high in IU and 16 subjects low in IU underwent an affective cueing paradigm where a warning cue signaled the vale...

journal_title：Neuroscience letters

authors： Gole M,Schäfer A,Schienle A

更新日期：2012-01-24 00:00:00

abstract：:The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potential...

journal_title：Neuroscience letters

authors： Lambert NA,Levitin M,Harrison NL

更新日期：1992-02-03 00:00:00

abstract：:The repressor element-1 silencing transcription factor (REST) has emerged as a key controller of neuronal differentiation and has been shown to play a critical role in the expression of the neuronal phenotype; however, much has still to be learned about its role at specific developmental stages and about the functiona...

journal_title：Neuroscience letters

authors： Antoniotti S,Ruffinatti FA,Torriano S,Luganini A,D'Alessandro R,Lovisolo D

更新日期：2016-08-26 00:00:00

abstract：:We have used in situ hybridization with biotinylated oligonucleotide (antisense) probes and streptavidin-biotinylated alkaline phosphatase method to detect the amount of amyloid beta-protein mRNA in the paraffin-embedded and formalin-fixed brain samples of patients affected by Alzheimer's disease and those of non-affe...

journal_title：Neuroscience letters

authors： Syrjänen S,Heinonen O,Miettinen R,Paljärvi L,Syrjänen K,Riekkinen P

更新日期：1991-09-02 00:00:00

abstract：:Pentobarbital anesthesia causes about a 10-fold increase in the antinociceptive potency of beta-endorphin microinjected into the periaqueductal gray (PAG) region of the rat brain. The antinociceptive response to PAG morphine was markedly attenuated during anesthesia, but returned as the rats regained consciousness. As...

journal_title：Neuroscience letters

authors： Smith DJ,Robertson B,Monroe PJ

更新日期：1992-11-09 00:00:00

abstract：:The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value ...

journal_title：Neuroscience letters

authors： Cartmell J,Kemp JA,Mutel V

更新日期：1997-06-13 00:00:00

abstract：:Alzheimer's disease (AD) brains contain high levels of advanced glycation endproducts (AGEs). Double immunostaining using anti-AGE and anti-apolipoprotein E (apoE) antibodies demonstrated that AGEs co-localized to a very high degree with apoE. We examined the binding of apoE to in vitro-prepared AGE-bovine serum album...

journal_title：Neuroscience letters

authors： Li YM,Dickson DW

更新日期：1997-05-02 00:00:00

abstract：:Using an antiserum (AS) raised against dynorphin B (DYN B), we revealed immunoreactive neurons in different nuclei of the rat hypothalamus as well as a population of neurons scattered in the lateral areas of the posterior hypothalamus. This population corresponds to that previously shown to be specifically recognized ...

journal_title：Neuroscience letters

authors： Griffond B,Deray A,Fellmann D,Ciofi P,Croix D,Bugnon C

更新日期：1993-06-25 00:00:00

abstract：:To determine whether axonal terminals emanating from the central nucleus of amygdala (Ce) to the parabrachial nucleus (PBN) contain gamma-aminobutyric acid (GABA) as their neurotransmitter, an electron microscopic study was performed employing the combined techniques of WGA-HRP anterograde tracing and post-embedding i...

journal_title：Neuroscience letters

authors： Jia HG,Zhang GY,Wan Q

更新日期：2005-07-01 00:00:00

abstract：:A newly isolated factor from mammalian brain, neurocatin, is shown to increase both the level and release of serotonin in suspensions of synaptosomes isolated from rat brain. Incubation of synaptosomes for 10 min with approximately 20 nM neurocatin resulted in release of about 50% of the total pool of serotonin. Quant...

journal_title：Neuroscience letters

authors： Fernandez-Novoa L,Pastuszko A

更新日期：1991-01-14 00:00:00

abstract：:Our previous studies have shown that acupuncture attenuates morphine self-administration and sensitization behavior as well as withdrawal signs. The present study was designed to investigate the role of acupuncture in the reinstatement of morphine seeking. Male Sprague-Dawley rats weighing 270-300 g were subjected to ...

journal_title：Neuroscience letters

authors： Lee BH,Ma JH,In S,Kim HY,Yoon SS,Jang EY,Yang CH

更新日期：2012-10-31 00:00:00

abstract：:In striatal neurons in primary culture quisqualate potently stimulated the formation of inositol phosphates via a metabotropic receptor we recently termed Qp in order to distinguish it from the classical ionotropic quisqualate receptor termed Qi. Here we show that 10 microM of quisqualate activated in a rapid and tran...

journal_title：Neuroscience letters

authors： Manzoni OJ,Finiels-Marlier F,Sassetti I,Blockaert J,le Peuch C,Sladeczek FA

更新日期：1990-02-05 00:00:00

abstract：:Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimul...

journal_title：Neuroscience letters

authors： Kamphuis W,Gorter JA,Wadman WJ,Lopes da Silva FH

更新日期：1992-07-06 00:00:00

abstract：:To assess the significance of the association between apolipoprotein E (APOE) epsilon 4 allele and amyloid beta-peptide (A-beta) deposits in the brain, we performed APOE-genotyping and measured the density of A-beta deposits, neuritic plaques and neurofibrillary tangles in 27 cases from the Charles Foix clinico-pathol...

journal_title：Neuroscience letters

authors： Berr C,Hauw JJ,Delaère P,Duyckaerts C,Amouyel P

更新日期：1994-09-12 00:00:00

abstract：:We assessed whether tolerance develops to the antinociceptive effect of intrathecal (i.t.) orphanin FQ, the endogenous ligand of the orphan opioid-like receptor, and whether there is a cross-tolerance between the antinociceptive effect of i.t. orphanin FQ and the mu opioid receptor agonist morphine. Orphanin FQ admini...

journal_title：Neuroscience letters

authors： Hao JX,Wiesenfeld-Hallin Z,Xu XJ

更新日期：1997-02-14 00:00:00

abstract：:Sodium butyrate (NaB) has exhibited neuroprotective activity. This study aimed to explore that NaB exerts beneficial effects on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors and its possible mechanisms. The behavioral tests including sucrose preference test (SPT), open field test (OFT), ta...

journal_title：Neuroscience letters

authors： Sun J,Wang F,Hong G,Pang M,Xu H,Li H,Tian F,Fang R,Yao Y,Liu J

更新日期：2016-04-08 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) has been demonstrated to be an important regulator of cell death and survival. Although it has been suggested that the sphingolipid may act as a neuroprotector in the cell apoptosis induced by traumatic brain injury, the mechanisms involved in this action are unknown. In this study, the r...

journal_title：Neuroscience letters

authors： Agudo-López A,Miguel BG,Fernández I,Martínez AM

更新日期：2010-02-12 00:00:00

abstract：:Dinucleotide repeat polymorphism has been observed in the promoter of the alpha-synuclein (alpha-SYN)/NAC precursor protein (NACP) gene. Alpha-SYN/NACP allele 3 (described by Xia et al. (Ann. Neurol., 40 (1996) 207), equivalent to allele 1 described by Krüger et al. (Ann. Neurol. 45 (1999) 611) is reported to be signi...

journal_title：Neuroscience letters

authors： Izumi Y,Morino H,Oda M,Maruyama H,Udaka F,Kameyama M,Nakamura S,Kawakami H

更新日期：2001-03-09 00:00:00

abstract：:Melatonin is the principle hormonal product of the pineal gland. It is secreted with a robust daily rhythm, peaking near the middle of the night. During the daytime, concentrations remain very low, as exposure to light robustly suppresses its secretion. The regulation of melatonin by light is well-characterized, but a...

journal_title：Neuroscience letters

authors： Bedrosian TA,Herring KL,Walton JC,Fonken LK,Weil ZM,Nelson RJ

更新日期：2013-05-10 00:00:00

abstract：:Light microscopic immunohistochemistry was used to investigate the presence and distribution of chromogranin A-like immunoreactivity in the human anal canal. In the anal transitional zone (ATZ), anal duct and anal gland epithelium, a varied number of mostly elongated cells strongly stained for CGA, using an antibody d...

journal_title：Neuroscience letters

authors： Weihe E,Hörsch D,Eiden LE,Hartschuh W

更新日期：1991-09-16 00:00:00

abstract：:Changes in adenosine 3',5'-cyclic monophosphate (cAMP) concentration were measured in cortical synaptosomes. Preincubation with adenosine deaminase reduced cAMP concentration by 45%. Oxotremorine, clonidine, gamma-aminobutyric acid (GABA) and baclofen produced no change in basal concentration. 2-Chloroadenosine and no...

journal_title：Neuroscience letters

authors： Fillenz M,Bloomfield MR

更新日期：1986-02-28 00:00:00

abstract：:Injections of a wheat germ agglutinin-horseradish peroxidase conjugate were placed in representative areas of the cerebellar cortex of adult tree shrews. Retrogradely labeled cells were found in the medial terminal nucleus (MTN) of the accessory optic system (AOS) when ventral portions of the uvula were involved in th...

journal_title：Neuroscience letters

authors： Haines DE,Sowa TE

更新日期：1985-04-09 00:00:00

abstract：:Survivors of bacterial meningitis frequently suffer from long-term sequelae, particularly from learning and memory deficits. For this reason, spatial memory and learning was studied in a mouse model of ceftriaxone-treated Streptococcus pneumoniae meningitis. Persistent deficits of spatial learning despite normal motor...

journal_title：Neuroscience letters

authors： Wellmer A,Noeske C,Gerber J,Munzel U,Nau R

更新日期：2000-12-22 00:00:00

abstract：:This study reports the solubilization of the rat synaptic vesicle protein SV2A, the brain binding site for the antiepileptic drug levetiracetam (LEV), and its characterization. N-dodecyl-beta-D-maltoside (DDM) was the best detergent at achieving a high percentage of SV2A solubilization and at maintaining the binding c...

journal_title：Neuroscience letters

authors： Lambeng N,Grossmann M,Chatelain P,Fuks B

更新日期：2006-05-01 00:00:00

abstract：:This paper presents additional evidence showing the persistent functional deficits in concussed athletes as revealed by altered movement-related cortical potentials (MRCP) preceding whole body postural movements at least 30 days post-injury. Eight student-athletes participated in this study (a) prior to injury; and (b...

journal_title：Neuroscience letters

authors： Slobounov S,Sebastianelli W,Moss R

更新日期：2005-08-05 00:00:00

abstract：:Neuronal nAChRs are pentameric transmembrane proteins which function as ligand-gated ion channels and are composed of multiple alpha and beta subunits. Nine neuronal nAChR alpha subunit genes (alpha2-alpha10) and three nAChR beta subunit genes (beta2-beta4) have been identified. nAChR subtypes are heteromers, composed...

journal_title：Neuroscience letters

authors： Danthi S,Boyd RT

更新日期：2006-05-29 00:00:00