Abstract：
:Although cAMP response element binding protein (CREB)- and extracellular-regulated protein kinase (ERK)-mediated pathways have been linked to each other in neuronal differentiation, involvement of these in hippocampal neuronal cell line has not been defined. Using an immortalized hippocampal cell line, HiB5, we have tried a pairing of forskolin with KCl depolarization, which acts as an ERK and CREB kinase activator in hippocampal neurons, to investigate if an activation of ERK and phosphorylation of CREB at the critical regulatory site, serine 133 might be coupled in differentiation. Differentiation toward a neuronal phenotype was synergistically and markedly increased by the pairing of forskolin and KCl depolarization. The synergistic effect was accompanied by an increase in phosphorylation of CREB Ser-133, but not phosphorylation of ERK, and was not inhibited by MEK inhibitor, PD98059. These findings indicate that phosphorylation of the transcriptional factor CREB may function to facilitate differentiation of HiB5 cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Son H,Kim KO,Kim JS,Chang MY,Lee SH,Lee YSdoi
10.1016/s0304-3940(01)01984-xkeywords:
subject
Has Abstractpub_date
2001-07-27 00:00:00pages
37-40issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(01)01984-Xjournal_volume
308pub_type
杂志文章abstract：:Because reelin and prestin genes are located close together on mouse chromosome 5, reelin homozygous mutant mice were compared with littermate controls. Experiments were designed to determine if the deletion in the reeler mouse affects the coding and/or regulatory regions for the expression of prestin, the outer hair ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00597-4
更新日期：2003-08-14 00:00:00
abstract：:The present work describes the formation of a transient efferent axonal projection from the isthmo-optic nucleus (ION) to the ipsilateral optic tectum of the chick embryo. Local application of either the carbocyanine dye DiI or rhodamine-B-isothiocyanate (RITC) to the superficial layers of the optic tectum resulted in...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90591-v
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90068-x
更新日期：1983-08-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90076-l
更新日期：1990-07-03 00:00:00
abstract：:Self-initiated leg movement in standing humans is preceded by a medio-lateral preparatory balance adjustment (PBA); however, such preparatory balance control is often absent in reflex-like stepping responses evoked by whole-body instability. The presence or absence of the PBA may reflect a task-dependent modulation of...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00365-1
更新日期：1999-06-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90368-5
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00599-8
更新日期：2003-08-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90218-2
更新日期：1988-06-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.02.056
更新日期：2010-04-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90622-1
更新日期：1986-12-03 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00838-3
更新日期：2003-10-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90094-a
更新日期：1991-04-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.09.018
更新日期：2016-10-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90505-4
更新日期：1990-05-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90263-5
更新日期：1984-09-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.05.005
更新日期：2006-12-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)12192-7
更新日期：1995-12-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00655-2
更新日期：1999-10-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00421-8
更新日期：1999-07-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2017-10-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.06.006
更新日期：2014-08-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00518-7
更新日期：1998-07-31 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1995-05-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90256-8
更新日期：1984-09-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90254-5
更新日期：1992-08-31 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.08.052
更新日期：2009-10-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.06.023
更新日期：2014-08-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.04.024
更新日期：2016-05-16 00:00:00
abstract：:A modified "cross-modal delayed response" paradigm was used to investigate putative processing of face expression in the absence of focused attention to the face. Neutral, happy and sad faces were presented during intervals occurring between a tone and a response imperative signal (a faint click), while subjects were ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.09.081
更新日期：2006-12-20 00:00:00
abstract：:Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patc...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90085-x
更新日期：1994-08-01 00:00:00
