Responses of regional cerebral blood flow to intravenous administration of thyrotropin releasing hormone in aged rats.

Abstract:

:The effects of i.v. administration of thyrotropin releasing hormone (TRH) on regional cerebral blood flow (rCBF) were examined in both healthy adult (3-5 months old) and healthy aged (24-25 months old) male Wistar rats under halothane anesthesia. The rCBFs in 9 different brain regions-cerebral cortex, caudate putamen, hippocampus, thalamus + hypothalamus, superior colliculus, inferior colliculus, cerebellum, pons, and medulla-were measured by [14C]iodoantipyrine method. In the adult rats, i.v. administration of TRH (300 micrograms/kg) produced significant increases in rCBFs in cerebral cortex, caudate putamen, hippocampus, thalamus + hypothalamus and superior colliculus. In the aged rats, the rCBFs in all brain regions measured did not change significantly by TRH administration. From these results, it is suggested that the system involved in TRH-induced vasodilatation of cerebral blood vessels was impaired with aging.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Inanami O,Ohno K,Sato A

doi

10.1016/0304-3940(92)90254-5

keywords:

subject

Has Abstract

pub_date

1992-08-31 00:00:00

pages

151-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90254-5

journal_volume

143

pub_type

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