Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat.

abstract：:8-Hydroxy-2-[di-n-propylamino]-tetralin) (8-OH-DPAT), a 5-HT1A/7 receptor agonist, has a chronobiological effect on the circadian system. To identify how the 8-OH-DPAT exerts this effect, we specifically destroyed the serotonergic (5-HT) fibres connecting the median raphe nuclei (RN) to the suprachiasmatic nuclei (SCN...

journal_title：Neuroscience letters

authors： Schuhler S,Saboureau M,Pitrosky B,Pévet P

更新日期：1998-10-30 00:00:00

abstract：:Spinal muscular atrophy (SMA), a primarily childhood form of motor neuron disease, is caused by reduced levels of a single, ubiquitously expressed protein: the survival motor neuron (SMN) protein. Low levels of SMN cause motor neuron degeneration but recent reports describe effects of low SMN levels in multiple tissue...

journal_title：Neuroscience letters

authors： Somers E,Riessland M,Schreml J,Wirth B,Gillingwater TH,Parson SH

更新日期：2013-06-07 00:00:00

abstract：:Neuroimmune mechanisms play critical roles in brain development and can be impacted by early life adversity. Microglia are the resident immune cells in the brain, with both sex-specific and region-specific developmental profiles. Since early life adversity is associated with several neuropsychiatric disorders with dev...

journal_title：Neuroscience letters

authors： Gildawie KR,Orso R,Peterzell S,Thompson V,Brenhouse HC

更新日期：2020-11-01 00:00:00

abstract：:Daily administration of clonidine for 5 weeks (approx. 300 micrograms/kg/day, p.o.) produced significant decreases in blood pressure and renal sympathetic efferent activity in spontaneously hypertensive rats (SHR). After cessation of clonidine administration, blood pressure and sympathetic nerve activity recovered rap...

journal_title：Neuroscience letters

authors： Yomaida I,Murao M,Togashi H,Shimamura K,Koike Y,Monma Y,Saito HA

更新日期：1979-12-01 00:00:00

abstract：:Glutamate receptor interacting protein (GRIP) is a member of the PDZ domain-containing protein family that is localized in the postsynaptic density area. This protein has been reported to interact specifically with the C-termini of AMPA-selective glutamate receptor channel subunits, GluRalpha2 and GluRalpha3 through i...

journal_title：Neuroscience letters

authors： Yamazaki M,Fukaya M,Abe M,Ikeno K,Kakizaki T,Watanabe M,Sakimura K

更新日期：2001-05-18 00:00:00

abstract：:Microglia are resident immune cells of brain and activated by peripheral tissue injury. In the present study, we investigated the possible induction of several microglial surface immunomolecules in the spinal cord, including leukocyte common antigen (LCA/CD45), MHC class I antigen, MHC class II antigen, Fc receptor, a...

journal_title：Neuroscience letters

authors： Fu KY,Tan YH,Sung B,Mao J

更新日期：2009-01-16 00:00:00

abstract：:We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertica...

journal_title：Neuroscience letters

authors： Veber D,Mutti E,Sironi L,Guerrini U,Gianazza E,Scalabrino G

更新日期：2008-08-08 00:00:00

abstract：:In this study we reported evidence for the existence of specific binding sites for platelet-activating factor (PAF) in neuroblastoma N1E-115 cells. The specific [3H]PAF binding reached a steady state level within 60 min at 25 degrees C. Scatchard analysis of the specific [3H]PAF binding revealed the presence of two ap...

journal_title：Neuroscience letters

authors： Lalouette F,Diserbo M,Martin C,Verdetti J,Fatome M

更新日期：1995-02-17 00:00:00

abstract：:Linkage studies have implicated a broad region on chromosome 10q in Alzheimer's disease (AD). A recent genetic association study has provided evidence that polymorphism in the gene encoding alpha-3 catenin (CTNNA3, referred to previously as VR22 and also known as alpha-T catenin) may underlie linkage signals. Here, to...

journal_title：Neuroscience letters

authors： Blomqvist ME,Andreasen N,Bogdanovic N,Blennow K,Brookes AJ,Prince JA

更新日期：2004-04-01 00:00:00

abstract：:Despite the crucial importance of direction of gaze in social interactions, it is only recently that there has been interest in human brain responses to gaze direction. Using full-head magnetoencephalography, we investigated the correlates of direction of gaze in full faces and in eyes-only stimuli, measuring the earl...

journal_title：Neuroscience letters

authors： Taylor MJ,George N,Ducorps A

更新日期：2001-12-28 00:00:00

abstract：:Although chlorpromazine was shown to greatly inhibit a Ca2+-mediated cell death at favorable concentrations (10(-6)-10(-5) M), it caused a drastic decrease in cell viability at higher concentrations (10(-4)-10(-3) M) in a human neuroblastoma cell line. The toxic effect of chlorpromazine also occurred in Ca2+-free medi...

journal_title：Neuroscience letters

authors： Abe K,Sekizawa T,Kogure K

更新日期：1986-11-21 00:00:00

abstract：:Oxygen tension is critical for proliferation of human and murine midbrain-derived neural precursor cells (mNPCs). Lack of hypoxia-inducible factor-1α (HIF1α) impairs midbrain dopaminergic neurogenesis which could be rescued by vascular endothelial growth factor (VEGF) via VEGFR-2 signaling. Here, we conditionally inac...

journal_title：Neuroscience letters

authors： Hermann A,Loewenbrück KF,Boldt Ä,Fiedler C,Maisel M,Kalucka J,Schwarz J,Breier G,Storch A

更新日期：2013-10-11 00:00:00

abstract：:Long-term adrenalectomy results in loss of neurones in the hippocampal formation of the adult rat. The effects of long-term adrenalectomy on spatial learning and exploratory behaviour in adrenalectomized (ADX), adrenalectomized normal weight gain (ADXNW), sham operated and naive control male Sprague-Dawley rats were i...

journal_title：Neuroscience letters

authors： Islam A,Henriksson B,Mohammed A,Winblad B,Adem A

更新日期：1995-07-14 00:00:00

abstract：:The effects of acute and subacute supramaximal and submaximal electroshock-induced convulsions on rat brain tribulin activity were investigated. Both supramaximal and submaximal shocks induced a marked increase, as measured 30 min after the onset of convulsions, with a significantly greater effect from the former. The...

journal_title：Neuroscience letters

authors： Bhattacharya SK,Banerjee PK,Glover V,Sandler M

更新日期：1991-04-15 00:00:00

abstract：:We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired perf...

journal_title：Neuroscience letters

authors： Nabeshima T,Ogawa S,Nishimura H,Fuji K,Kameyama T,Sasaki Y

更新日期：1991-01-14 00:00:00

abstract：:CART peptides are important neurotransmitters, but little is known about their receptors or signaling pathways in cells. In this study we describe the effects of CART 55-102 on the stimulation of extracellular signal-related kinase (ERK) in a pituitary-derived cell line. CART 55-102 treatment resulted in markedly enha...

journal_title：Neuroscience letters

authors： Lakatos A,Prinster S,Vicentic A,Hall RA,Kuhar MJ

更新日期：2005-08-12 00:00:00

abstract：:The restoration of motor function is important in daily life in patients with brain damage. Although attentional concentration can affect motor function, most physical therapists focus only on therapeutic exercise. Therefore, we investigated changes in motor function in patients with high attentional concentration dur...

journal_title：Neuroscience letters

authors： Ha SY,Sung YH

更新日期：2020-09-25 00:00:00

abstract：:Cholinergic amacrine cells in the rabbit retina have been detected by localizing choline acetyltransferase-like immunoreactivity. The characteristic array of normally placed and displaced amacrine cells was detected, as were two major synaptic plexuses in the inner plexiform layer. At the ultrastructural level, the mo...

journal_title：Neuroscience letters

authors： Millar TJ,Morgan IG

更新日期：1987-03-09 00:00:00

abstract：:Glucose homeostasis was studied in the spontaneously hypertensive rat (SHR). The fasting plasma glucose levels were similar in the SHR and normotensive Wistar-Kyoto (WKY) rat (102.7+/-2.4 vs. 107.4+/-4.2 mg/dl, P > 0.01). One hour after glucose challenge, the plasma glucose level was slightly but insignificantly incre...

journal_title：Neuroscience letters

authors： Tong YC,Wang CJ,Cheng JT

更新日期：1997-09-19 00:00:00

abstract：:Heme oxygenase (HO-1) gene expression was studied in the brains of rats subjected to 30 min global cerebral ischemia followed by recirculation of up to 24 h. Total RNA was isolated from the cerebral cortex, striatum and hippocampus and reverse-transcribed into cDNA. cDNA was taken as template for PCR using HO-1-specif...

journal_title：Neuroscience letters

authors： Paschen W,Uto A,Djuricic B,Schmitt J

更新日期：1994-10-10 00:00:00

abstract：:Several evidences have pointed to biochemical alterations in some brain structures after experimental Status Epilepticus (SE). Thus, the effects of pilocarpine-induced SE on the glutamate binding in the hippocampus and cortex of Wistar rats were evaluated. Groups of animals were submitted to a 3h SE induced by intrahi...

journal_title：Neuroscience letters

authors： Cunha AO,Mortari MR,Carolino RO,Coutinho-Netto J,Dos Santos WF

更新日期：2007-08-31 00:00:00

abstract：:Recent neuroimaging studies indicate that there may be common ground for esthetic and moral judgments. However, because previous studies focused on either esthetic or moral judgments and did not compare the two directly, the issue remains open whether a common ground actually exists. We employed functional magnetic re...

journal_title：Neuroscience letters

authors： Avram M,Gutyrchik E,Bao Y,Pöppel E,Reiser M,Blautzik J

更新日期：2013-02-08 00:00:00

abstract：:Although the main source of circulating ghrelin is the stomach, it is also present in physiologically relevant amounts in the hypothalamus. It is reported that pharmacological doses of melatonin decrease blood levels of ghrelin. Thus, melatonin (MT) may be a candidate for the regulation of ghrelin synthesis in the bra...

journal_title：Neuroscience letters

authors： Canpolat S,Aydin M,Yasar A,Colakoglu N,Yilmaz B,Kelestimur H

更新日期：2006-12-20 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS(+)) is a common familial epilepsy syndrome, which generally develops in childhood. GEFS(+) is caused by mutations in the sodium-channel α1-subunit (SCN1A). In this report, we investigated a Chinese family with an autosomal dominant form of GEFS(+). The affected GEF...

journal_title：Neuroscience letters

authors： Cui X,Zeng F,Liu Y,Zhang J,Archacki S,Zhan T,Du R,Tang Z,Liu J,Wang QK,Liu M

更新日期：2011-09-26 00:00:00

abstract：:Dopaminergic brain systems have been implicated to play a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The cocaine- and amphetamine-regulated transcript peptide (CARTPT) is involved in reward and feeding behavior and has fun...

journal_title：Neuroscience letters

authors： Lohoff FW,Bloch PJ,Weller AE,Nall AH,Doyle GA,Buono RJ,Ferraro TN,Kampman KM,Pettinati HM,Dackis CA,Oslin DW,O'Brien CP,Berrettini WH

更新日期：2008-08-08 00:00:00

abstract：:The purpose of this investigation was to evaluate the effect and mechanisms of electroacupuncture (EA) at the bilateral Zusanli acupoints (ST-36) on glucose tolerance in normal rats. Intravenous glucose tolerance test (IVGTT) was performed to examine the effects of electroacupuncture (EA) on glucose tolerance in rats....

journal_title：Neuroscience letters

authors： Lin RT,Chen CY,Tzeng CY,Lee YC,Cheng YW,Chen YI,Ho WJ,Cheng JT,Lin JG,Chang SL

更新日期：2011-04-25 00:00:00

abstract：:The etiology of schizophrenia is unknown, but the pathogenetic process involves organic changes in brain tissue, which may alter the composition of cerebrospinal fluid (CSF). For the present study, CSF was obtained by lumbar puncture from 22 schizophrenic patients and 38 control patients. We have used scanning electro...

journal_title：Neuroscience letters

authors： Wetterberg L,Nybom R,Bratlid T,Fladby T,Olsson B,Wigzell H

更新日期：2002-08-23 00:00:00

abstract：:Stereotaxic injections of ibotenic acid (IBO) and kainic acid (KA) into either the dorsal hippocampus or the lateral cerebroventricle were performed in order to determine the relative potencies of the drugs and the vulnerability of different hippocampal cell types to their neurotoxic action, IBO was found to be approx...

journal_title：Neuroscience letters

authors： Köhler C,Schwarcz R,Fuxe K

更新日期：1979-12-01 00:00:00

abstract：:Pharmacological blocking agents were used to assess the contributions of different K(+)-currents to spike-repolarization and early spike-afterhyperpolarization recorded in dissociated, tissue-cultured rat superior cervical sympathetic neurones using both patch-clamp and impalement microelectrode techniques. Effects of...

journal_title：Neuroscience letters

authors： Marsh SJ,Brown DA

更新日期：1991-12-09 00:00:00

abstract：:Exposure to manganese in an industrial or clinical setting can lead to manganism, a neurological disorder with similarities to Parkinson's disease. Although the pathogenetic basis of this disorder is unclear, studies indicate this metal is highly accumulated in astrocytes, suggesting an involvement of these glial cell...

journal_title：Neuroscience letters

authors： Hazell AS,Normandin L,Norenberg MD,Kennedy G,Yi JH

更新日期：2006-04-03 00:00:00