Abstract:
:Long-term adrenalectomy results in loss of neurones in the hippocampal formation of the adult rat. The effects of long-term adrenalectomy on spatial learning and exploratory behaviour in adrenalectomized (ADX), adrenalectomized normal weight gain (ADXNW), sham operated and naive control male Sprague-Dawley rats were investigated in this study. The ADX rats had significantly longer latencies in the Morris maze task compared to the other groups. In the open-field situation, as a novel finding, the ADX rats showed significantly lower rearing scores compared to other groups. These data indicate that long-term adrenalectomy causes impairment in spatial learning and explorative behaviour in the rat.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Islam A,Henriksson B,Mohammed A,Winblad B,Adem Adoi
10.1016/0304-3940(95)11724-bsubject
Has Abstractpub_date
1995-07-14 00:00:00pages
49-52issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(95)11724-Bjournal_volume
194pub_type
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