Behavioural deficits in adult rats following long-term adrenalectomy.

Abstract:

:Long-term adrenalectomy results in loss of neurones in the hippocampal formation of the adult rat. The effects of long-term adrenalectomy on spatial learning and exploratory behaviour in adrenalectomized (ADX), adrenalectomized normal weight gain (ADXNW), sham operated and naive control male Sprague-Dawley rats were investigated in this study. The ADX rats had significantly longer latencies in the Morris maze task compared to the other groups. In the open-field situation, as a novel finding, the ADX rats showed significantly lower rearing scores compared to other groups. These data indicate that long-term adrenalectomy causes impairment in spatial learning and explorative behaviour in the rat.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Islam A,Henriksson B,Mohammed A,Winblad B,Adem A

doi

10.1016/0304-3940(95)11724-b

subject

Has Abstract

pub_date

1995-07-14 00:00:00

pages

49-52

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)11724-B

journal_volume

194

pub_type

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