Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.

abstract：:In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive calcitonin gene-related peptide (irCGRP) in the lumbar dorsal horn during stimulation of non-nociceptive or nociceptive primary afferent fibres. Release of irCGRP was detected in the substantia gelatinosa, where immunostaini...

journal_title：Neuroscience letters

authors： Morton CR,Hutchison WD

更新日期：1990-09-18 00:00:00

abstract：:Senile plaques (SPs) and cerebral amyloid angiopathy (CAA) in the brains of five aged (20-26 years old) cynomolgus monkeys were investigated immunohistochemically using two monoclonal antibodies (anti-A beta 40 (BA27) and anti-A beta 42(43) (BC05)) that can differentiate the carboxyl termini of amyloid beta protein (A...

journal_title：Neuroscience letters

authors： Nakamura S,Tamaoka A,Sawamura N,Shoji S,Nakayama H,Ono F,Sakakibara I,Yoshikawa Y,Mori H,Goto N

更新日期：1995-12-08 00:00:00

abstract：:The effects of Ga-Al-As diode laser (830 nm, 16.2 mW) irradiation on the distal portion of the processes of cultured murine dorsal root ganglion (DRG) neurons associated with C-fibers were studied by patch-clamp whole-cell recording of membrane potentials at the cell body. The chemical as well as laser light stimulati...

journal_title：Neuroscience letters

authors： Jimbo K,Noda K,Suzuki K,Yoda K

更新日期：1998-01-09 00:00:00

abstract：:Sinomenine, one of the alkaloids extracted from roots or stems of Sinomenium acutum, is documented to show antinociceptive action but the action mechanism is still unclear. The present study was aimed to investigate the effect of sinomenine on opioid mu-receptor (OMR). In Chinese Hamster Ovary (CHO) cell transfected w...

journal_title：Neuroscience letters

authors： Wang MH,Chang CK,Cheng JH,Wu HT,Li YX,Cheng JT

更新日期：2008-10-10 00:00:00

abstract：:We present results of homozygosity mapping in two siblings affected with early onset Parkinson's disease (EOPD) and mutation screening of ATP13A2 in these and other Iranian EOPD patients. Genome-wide SNP homozygosity analysis revealed linkage to a locus that included ATP13A2, and sequencing of the gene revealed a nove...

journal_title：Neuroscience letters

authors： Malakouti-Nejad M,Shahidi GA,Rohani M,Shojaee SM,Hashemi M,Klotzle B,Fan JB,Elahi E

更新日期：2014-08-08 00:00:00

abstract：:The modulation by endogenous polyamine spermine on acetylcholine (ACh)-induced currents was evaluated using a outside-out patch and whole-cell voltage-clamp recordings from cultured Xenopus muscle cells. Spermine potentiated the ACh-induced whole-cell currents at micromolar concentrations but is less effective at mill...

journal_title：Neuroscience letters

authors： Hsu KS

更新日期：1994-11-21 00:00:00

abstract：:Treatment with agmatine, decarboxylated arginine, proved to be non-toxic and to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove beneficial in a rat spinal cord ischemia model (balloon occlu...

journal_title：Neuroscience letters

authors： Gilad GM,Gilad VH

更新日期：2000-12-22 00:00:00

abstract：:Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and beneficially contributes to cognitive function and is accompanied by epigenetic changes. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylat...

journal_title：Neuroscience letters

authors： Li X,Inoue T,Hayashi M,Maejima H

更新日期：2019-07-27 00:00:00

abstract：:To investigate injury-induced alterations of purinergic P2Y receptor-mediated calcium responses in glial (Müller) cells of the rabbit retina, neural retinae were experimentally detached from the pigment epithelium. The ATP-evoked calcium responses were recorded in the endfeet of glial cells at the vitread surface of r...

journal_title：Neuroscience letters

authors： Uckermann O,Uhlmann S,Weick M,Pannicke T,Francke M,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2003-02-27 00:00:00

abstract：:The aim of the present study is to investigate the mechanisms of suppression of splenic natural killer (NK) cytotoxicity caused by cold stress, using 6-hydroxydopamine (6-OHDA) as chemical sympathectomy. The NK activity was measured by (51)chromium release assay. Central sympathectomy with intracerebroventricular inje...

journal_title：Neuroscience letters

authors： Jiang XH,Guo SY,Xu S,Yin QZ,Ohshita Y,Naitoh M,Horibe Y,Hisamitsu T

更新日期：2004-03-18 00:00:00

abstract：:Five picrotoxinin analogues were examined on GABA-gated chloride channels of an identifiable cockroach (Periplaneta americana) motor neurone (Df). Substitution of the bridgehead hydroxyl at the C-6 position of the picrotoxinin molecule by a fluorine atom (fluoropicrotoxinin) had little effect, whereas acetylation of t...

journal_title：Neuroscience letters

authors： Anthony NM,Holyoke CW Jr,Sattelle DB

更新日期：1994-04-25 00:00:00

abstract：:The objective of the study was to investigate the presence and distribution of nerve cell bodies and small ganglia in the stroma of human submandibular gland. A retrospective immunohistochemical study in 13 human submandibular glands, fixed in neutral buffered formalin and embedded in paraffin wax, was undertaken. Six...

journal_title：Neuroscience letters

authors： Tosios KI,Nikolakis M,Prigkos AC,Diamanti S,Sklavounou A

更新日期：2010-05-07 00:00:00

abstract：:Online shopping festivals play a significant role in consumers' purchase decision and have been the focus of much research and many marketing practices. However, research has yet to explore which product categories can promote consumer purchase intention during online shopping festivals. This study carried out a neuro...

journal_title：Neuroscience letters

authors： Shang Q,Jin J,Qiu J

更新日期：2020-01-10 00:00:00

abstract：:The deposition of amyloid beta protein (Abeta), a proteolytic cleavage product of amyloid precursor protein (APP), is an invariable pathological feature of the Alzheimer's disease brain, while APP gene is widely expressed in all neuronal and non-neuronal tissues with the highest levels of expression in the brain, and ...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Yamaguchi H,Tateno M,Imai K,Fujii N,Yamauchi T

更新日期：2000-03-10 00:00:00

abstract：:Treatment with acamprosate, a compound used for relapse prevention treatment of alcoholism, was recently shown to be associated with increased plasma concentration of beta-endorphin in rats selectively bred for high alcohol preference. The aim of our study was to prove this result in a comparative clinical study with ...

journal_title：Neuroscience letters

authors： Kiefer F,Jahn H,Otte C,Nakovics H,Wiedemann K

更新日期：2006-08-14 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by neuroinflammation and demyelination that are mediated by T cells. The prolonged survival of autoreactive T cells acts as a primary event to trigger an inflammatory cascade that mediates myelin loss and clinical relapse in MS. Recently, T cell survival h...

journal_title：Neuroscience letters

authors： Yin L,Liu J,Dong H,Xu E,Qiao Y,Wang L,Zhang L,Jia J,Li L,Geng X

更新日期：2014-03-06 00:00:00

abstract：:The discharge of 38 tibialis anterior (TA) muscle spindle endings was recorded at rest and during isometric voluntary contraction of the ankle joint in eight healthy human subjects. With the ankle joint in 110 degrees plantarflexion, 24 endings (61%) were tonically active in the resting subject. During weak voluntary ...

journal_title：Neuroscience letters

authors： Nielsen J,Nagaoka M,Kagamihara Y,Kakuda N,Tanaka R

更新日期：1994-04-11 00:00:00

abstract：:Prophylaxis of posttraumatic epilepsy will require a detailed knowledge of the epileptogenic pathophysiological processes that follow brain injury. Results from studies of experimental models and human epilepsy highlight alterations in GABAergic interneurons and formation of excessive new excitatory synaptic connectiv...

journal_title：Neuroscience letters

authors： Li H,McDonald W,Parada I,Faria L,Graber K,Takahashi DK,Ma Y,Prince D

更新日期：2011-06-27 00:00:00

abstract：:In the present study we investigate the inhibitory circuitries that regulate the neuronal activity in the lateral and basal nuclei, which are the main sensory input regions of the amygdala. Axon terminals immunoreactive for parvalbumin, a calcium-binding protein known to colocalize with GABA, were examined in these re...

journal_title：Neuroscience letters

authors： Sorvari H,Miettinen R,Soininen H,Pitkänen A

更新日期：1996-10-18 00:00:00

abstract：:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 k...

journal_title：Neuroscience letters

authors： Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione B

更新日期：1994-04-25 00:00:00

abstract：:It was established that stimulation of the lateral hypothalamus (LH) can induce antinociception. Previous studies showed a role for the ventral tegmental area (VTA) and nucleus accumbens (NAc) in antinociception induced by LH stimulation through the orexinergic system. In this study, we tried to assess the involvement...

journal_title：Neuroscience letters

authors： Moradi M,Fatahi Z,Haghparast A

更新日期：2015-07-10 00:00:00

abstract：:Ascending thalamo-telencephalic projection systems have been investigated in an urodele, Triturus alpestris, using the horseradish peroxidase technique. Two separate dorsal thalamic projections onto the telencephalon have been identified; one arises from the posterior dorsal thalamus and terminates in the ipsilateral ...

journal_title：Neuroscience letters

authors： Wicht H,Himstedt W

更新日期：1986-07-11 00:00:00

abstract：:Basal and interferon (IFN)-induced levels of (2'-5') oligoadenylate synthetase activity were measured in astrocyte cultures from the mouse cerebral cortex, in neurone-enriched and mixed cerebellar cultures, and in two continuous neural cell lines by a radioimmunoassay procedure. All untreated cultures contained measur...

journal_title：Neuroscience letters

authors： Hirsch MR,Cailla H,Wietzerbin J,Goridis C

更新日期：1986-04-11 00:00:00

abstract：:FasL has been shown to induce angiogenesis in vivo, however, the mechanism remains to be determined. We have previously shown that Fas ligation induces expression of chemokines such as interleukin-8 by human astrogliomas, which may partially explain the in vivo angiogenic property of FasL. Intercellular adhesion molec...

journal_title：Neuroscience letters

authors： Choi K,Benveniste EN,Choi C

更新日期：2003-11-27 00:00:00

abstract：:Mutations in presenilins are the major cause of early onset familial Alzheimer disease. It has recently been argued that clinical presenilin mutations work as loss-of-function but not toxic gain-of-function. To investigate whether presenilins are involved in the regulation of the distribution of neuronal membrane lipi...

journal_title：Neuroscience letters

authors： Oikawa N,Goto M,Ikeda K,Taguchi R,Yanagisawa K

更新日期：2012-09-06 00:00:00

abstract：:Accurate and reliable prognostic judgments for disorders of consciousness (DOCs) can provide useful information for clinicians in the establishment of appropriate care plan, and may affect end-of-life decisions of caregivers. But until now no certain or standardized prognostic indicator has been constructed to predict...

journal_title：Neuroscience letters

authors： Zhang Y,Li R,Du J,Huo S,Hao J,Song W

更新日期：2017-07-13 00:00:00

abstract：:Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1991-04-01 00:00:00

abstract：:Plasminogen belongs to the plasminogen activator system of cell signaling proteins and has recently been identified to bind to pathological prion protein PrPSC, but not to its normal conformer, PrPC. Plasminogen binds specifically to the urokinase-type plasminogen activator receptor (uPAR) to promote pericellular prot...

journal_title：Neuroscience letters

authors： Deininger MH,Trautmann K,Magdolen V,Luther T,Schluesener HJ,Meyermann R

更新日期：2002-05-10 00:00:00

abstract：:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the c...

journal_title：Neuroscience letters

authors： Braestrup C,Nielsen M,Biggio G,Squires RF

更新日期：1979-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...

journal_title：Neuroscience letters

authors： Wen X,Westergard T,Pasinelli P,Trotti D

更新日期：2017-01-01 00:00:00