Morphine does not reduce the intraspinal release of calcitonin gene-related peptide in the cat.

Abstract:

:In anaesthetised cats, antibody microprobes were used to measure the release of immunoreactive calcitonin gene-related peptide (irCGRP) in the lumbar dorsal horn during stimulation of non-nociceptive or nociceptive primary afferent fibres. Release of irCGRP was detected in the substantia gelatinosa, where immunostaining for CGRP was subsequently observed. Intravenous administration of morphine did not affect release of irCGRP detected during either non-nociceptive or nociceptive afferent stimulation. The results suggest that the analgesic action of morphine does not involve reduced release of CGRP from the central terminals of nociceptive primary afferents.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Morton CR,Hutchison WD

doi

10.1016/0304-3940(90)90684-2

subject

Has Abstract

pub_date

1990-09-18 00:00:00

pages

319-24

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90684-2

journal_volume

117

pub_type

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