Parvalbumin-immunoreactive neurons make inhibitory synapses on pyramidal cells in the human amygdala: a light and electron microscopic study.

Abstract:

:In the present study we investigate the inhibitory circuitries that regulate the neuronal activity in the lateral and basal nuclei, which are the main sensory input regions of the amygdala. Axon terminals immunoreactive for parvalbumin, a calcium-binding protein known to colocalize with GABA, were examined in these regions with electron microscopy, and their postsynaptic targets were identified and characterized. In the lateral nucleus, parvalbumin-immunoreactive (PV-ir) axons formed terminal rows which made symmetric synaptic contacts on the axon initial segments of the pyramidal cells. In the basal nucleus, pericellular baskets of PV-ir fibers established symmetric synapses on pyramidal cell somata and proximal dendrites. Our data suggest that PV-ir neurons play a crucial inhibitory role in the control of pyramidal cell activity in the human amygdala.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sorvari H,Miettinen R,Soininen H,Pitkänen A

subject

Has Abstract

pub_date

1996-10-18 00:00:00

pages

93-6

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(96)13067-6

journal_volume

217

pub_type

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