Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor.

abstract：:The objective of the study was to investigate the presence and distribution of nerve cell bodies and small ganglia in the stroma of human submandibular gland. A retrospective immunohistochemical study in 13 human submandibular glands, fixed in neutral buffered formalin and embedded in paraffin wax, was undertaken. Six...

journal_title：Neuroscience letters

authors： Tosios KI,Nikolakis M,Prigkos AC,Diamanti S,Sklavounou A

更新日期：2010-05-07 00:00:00

abstract：:The volume density of mast cells was estimated in nerve end neuromas at various time-points after transection of the left sciatic nerve of 6-week-old mice. After an initial reduction in the amount of mast cells there was a steady increase with numerous cells in 6-month-old neuromas. The variation in amount of mast cel...

journal_title：Neuroscience letters

authors： Nennesmo I,Reinholt F

更新日期：1986-09-12 00:00:00

abstract：:Herpes simplex virus encephalitis (HSVE) causes elevated morbidity and mortality despite antiviral treatment. Virus-independent mechanisms may perpetuate brain damage. Matrix metalloproteinases (MMPs) target extracellular matrix components. This study describes the protein and mRNA expression of MMP2 and MMP9 in exper...

journal_title：Neuroscience letters

authors： Martínez-Torres FJ,Wagner S,Haas J,Kehm R,Sellner J,Hacke W,Meyding-Lamadé U

更新日期：2004-09-30 00:00:00

abstract：:The mRNA encoding the POU family transcription factor Oct-2 is induced in cultured adult sensory neurons following treatment with nerve growth factor (NGF) but not with a variety of other growth factors. We show here that the Oct-2 mRNA is also upregulated in vivo in sensory neurons innervating inflamed tissue followi...

journal_title：Neuroscience letters

authors： Ensor E,Kendall G,Allchorne A,Woolf CJ,Latchman DS

更新日期：1996-02-02 00:00:00

abstract：:We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertica...

journal_title：Neuroscience letters

authors： Veber D,Mutti E,Sironi L,Guerrini U,Gianazza E,Scalabrino G

更新日期：2008-08-08 00:00:00

abstract：:The ubiquitin carboxy-terminal hydrolase L1gene (UCH-L1) has been implicated in the aetiology of Parkinson's disease (PD). A rare Ile93Met mutation in UCH-L1 in a German PD sib-pair has been reported. Recently, a S18Y (C54A) polymorphism in exon 3 of UCH-L1 was found to be under-represented in PD patients compared to ...

journal_title：Neuroscience letters

authors： Mellick GD,Silburn PA

更新日期：2000-10-27 00:00:00

abstract：:Prostaglandins (PGs) were measured in perfusate from the lumbar intrathecal (IT) space of pentobarbital anaesthetized rats. The level of PGE2, but not of PGF2 alpha or 6-keto PGF1 alpha, was increased by immersion of a hindpaw in water at a noxious temperature (50 degrees C). No increase in PGE2 was produced by non-no...

journal_title：Neuroscience letters

authors： Coderre TJ,Gonzales R,Goldyne ME,West J,Levine JD

更新日期：1990-07-31 00:00:00

abstract：:Taurine increases in brain extracellular space due to glutamate agonists were studied in vivo in the rat hippocampus using a dialysis technique, both in the absence and in the presence of glutamate receptor antagonists. Extracellular taurine levels increased during perfusions of agonists, listed in descending order of...

journal_title：Neuroscience letters

authors： Menéndez N,Herreras O,Solis JM,Herranz AS,Martín del Río R

更新日期：1989-07-17 00:00:00

abstract：:We have previously demonstrated that repeated exposure of adult rat hippocampal slices to brief episodes of hypoxia induce a sustained decrease in the threshold of stimulus-evoked population spike discharges in CA1 pyramidal neurons [O. Godukhin, A. Savin, S. Kalemenev, S. Levin, Neuronal hyperexcitability induced by ...

journal_title：Neuroscience letters

authors： Levin S,Godukhin O

更新日期：2005-03-22 00:00:00

abstract：:A marked depression of evoked CA1 potentials was observed with the nucleotide analogues a,b-methylene ADP (AOPCP) and adenylimido-diphosphate (AIP) and with 2'-adenosine monophosphate (2'-AMP). While the depression elicited by 5'-nucleotides was completely antagonized by the action of adenosine deaminase, AOPCP and 2'...

journal_title：Neuroscience letters

authors： Lee KS,Schubert P,Emmert H,Kreutzberg GW

更新日期：1981-05-29 00:00:00

abstract：:The potential of nitric oxide for the induction of reactive oxygen species (ROS) has been evaluated in a cerebral synaptosomal fraction. Nitric oxide (NO) was generated using S-nitroso-N-acetylpenicillamine (SNAP). NO stimulated ROS production, assayed using a fluorescent probe. This stimulation was largely inhibited ...

journal_title：Neuroscience letters

authors： Bondy SC,Naderi S

更新日期：1994-02-28 00:00:00

abstract：:Presenilin-1 (PSEN1) mutations I143T and G384A give rise to severe early onset Alzheimers's disease in two extensively studied Belgian families, AD/A and AD/B. In this study we investigated the influence of the I143T and G384A mutations on PSEN1 proteolytic processing. Hereto we analyzed PSEN1 processing in lymphoblas...

journal_title：Neuroscience letters

authors： Vanderhoeven I,Cras P,Martin JJ,Van Broeckhoven C,De Jonghe C

更新日期：1999-10-29 00:00:00

abstract：:To elucidate the early histopathological changes after transient focal cerebral ischemia, we made 1 h intraluminal occlusion of the middle cerebral artery on rats. After different reperfusion time, from minutes to 3 days, argyrophil III method was used for the demonstration of 'collapsed' (argyrophilic, dark) neurons....

journal_title：Neuroscience letters

authors： Czurkó A,Nishino H

更新日期：1993-11-12 00:00:00

abstract：:1,3-di(2-[5-3H]tolyl)Guanidine ([3H]DTG) was found to bind to a single saturable population of binding sites in human cerebral cortex and NCB20 cells, a second low-affinity site was apparent in guinea pig brain. Displacement studies were performed to determine the pharmacology of the [3H]DTG binding site in these 3 me...

journal_title：Neuroscience letters

authors： Knight AR,Gillard J,Wong EH,Middlemiss DN

更新日期：1991-10-14 00:00:00

abstract：:The effects of i.v. administration of thyrotropin releasing hormone (TRH) on regional cerebral blood flow (rCBF) were examined in both healthy adult (3-5 months old) and healthy aged (24-25 months old) male Wistar rats under halothane anesthesia. The rCBFs in 9 different brain regions-cerebral cortex, caudate putamen,...

journal_title：Neuroscience letters

authors： Inanami O,Ohno K,Sato A

更新日期：1992-08-31 00:00:00

abstract：:In decerebrated rabbits, reflexes were evoked in medial gastrocnemius motoneurones by mechanical stimulation of the heel, using four pinch strengths from 183 (innocuous) to 4577 (noxious) mN. The alpha(2)-adrenoceptor antagonist idazoxan (1-156 microg intrathecal (i.th.) significantly increased responses to pinch stre...

journal_title：Neuroscience letters

authors： Clarke RW,Harris J,Houghton AK

更新日期：2001-08-10 00:00:00

abstract：:Many recent studies have revealed the consistency of anticipatory postural adjustments preceding single leg movements, such as stepping, in standing humans. These adjustments appear to involve an active lateral transfer of weight to the stance leg. The present study demonstrates that these anticipatory adjustments oft...

journal_title：Neuroscience letters

authors： McIlroy WE,Maki BE

更新日期：1993-12-24 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) has an antalgic effect on acute experimental pain in healthy volunteers. Many published studies have used online stimulation (i.e., tDCS performed during painful stimulation). On the other hand, daily tDCS sessions have been proposed as ...

journal_title：Neuroscience letters

authors： Brasil-Neto JP,Iannone A,Caixeta FV,Cavendish BA,de Mello Cruz AP,Buratto LG

更新日期：2020-09-25 00:00:00

abstract：:Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotect...

journal_title：Neuroscience letters

authors： Pringle AK,Niyadurupola N,Johns P,Anthony DC,Iannotti F

更新日期：2001-06-01 00:00:00

abstract：:Which cognitive processes are reflected by the N400 in ERPs is still controversial. Various recent articles (Lau et al., 2008; Brouwer et al., 2012) have revived the idea that only lexical pre-activation processes (such as automatic spreading activation, ASA) are strongly supported, while post-lexical integrative proc...

journal_title：Neuroscience letters

authors： Steinhauer K,Royle P,Drury JE,Fromont LA

更新日期：2017-06-09 00:00:00

abstract：:The mouse dopamine D4 receptor gene was isolated from a genomic DNA library by plaque hybridization. The D4 receptor gene encoded an open reading frame consisting of 387 amino acids, interrupted by three introns. Distribution of the D4 receptor mRNA in brain regions and peripheral tissues of mice was examined by rever...

journal_title：Neuroscience letters

authors： Suzuki T,Kobayashi K,Nagatsu T

更新日期：1995-10-13 00:00:00

abstract：:Pharmacogenetic studies assessing the role of 5-HT(2A) receptor gene in antipsychotic efficacy yielded conflicting data. Phenotypical heterogeneity of schizophrenia might explain such discrepancies. For example, negative symptoms are known to reflect severity of illness and to restrain therapeutic response. On this ba...

journal_title：Neuroscience letters

authors： Hamdani N,Bonnière M,Adès J,Hamon M,Boni C,Gorwood P

更新日期：2005-03-22 00:00:00

abstract：:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited AD...

journal_title：Neuroscience letters

authors： Morrisett RA

更新日期：1994-02-14 00:00:00

abstract：:The distribution of L-3,4-dihydroxy-[3H]phenylalanine (L-[3H]DOPA) was examined in rats following i.v. injection, to ascertain the possible usefulness of using this ligand to image dopaminergic systems using positron emission tomography. It was found that L-DOPA and its metabolites were preferentially localized in the...

journal_title：Neuroscience letters

authors： Liskowsky DR,Potter LT

更新日期：1985-01-21 00:00:00

abstract：:We characterized muscarnic and purinergic receptors and urodynamic parameters in the bladder of cyclophosphamide (CYP)-treated rats to clarify the mechanisms involved in the pathophysiology of interstitial cystitis (IC). In the cystometry of CYP-treated rats compared with control rats, the micturition interval and mic...

journal_title：Neuroscience letters

authors： Kageyama A,Fujino T,Taki Y,Kato Y,Nozawa Y,Ito Y,Yamada S

更新日期：2008-05-02 00:00:00

abstract：:We present a comprehensive analysis of the change in event-related potential (ERP) due to task difficulty during a visual oddball task. Specifically, we investigated the inter-subject difference in difficulty-related change of ERP patterns using single-trial ERP analysis focusing on P300 and P2 components. ERPs were r...

journal_title：Neuroscience letters

authors： Kim KH,Kim JH,Yoon J,Jung KY

更新日期：2008-11-14 00:00:00

abstract：:The extracellular homeostasis of glutamate in the brain is maintained by the efficient uptake into astroglial cells. The high extracellular glutamate levels seen during seizures are therefore probably a result of both an increased synaptic release and a deranged glutamate uptake. In this study we used immuno-blotting ...

journal_title：Neuroscience letters

authors： Samuelsson C,Kumlien E,Flink R,Lindholm D,Ronne-Engström E

更新日期：2000-08-11 00:00:00

abstract：:Cocaethylene is an active cocaine metabolite that targets mammalian neural reward pathways and thus contributes to the reinforcing and addictive properties of ethanol and cocaine. Using gas chromatography-mass spectrometry, we find that fruit flies (Drosophila melanogaster) possess a cellular mechanism through which c...

journal_title：Neuroscience letters

authors： Torres G,Horowitz JM

更新日期：1999-03-26 00:00:00

abstract：:Depression is among the leading causes of disability and disease burden. Recent studies point to an involvement of altered serotonin1A receptor (5-HT1AR) -mediated adult neurogenesis in depression. However, the exact underlying mechanisms remain unclear, mainly due to the complexity of the serotonergic system with its...

journal_title：Neuroscience letters

authors： Noto B,Klempin F,Alenina N,Bader M,Fink H,Sander SE

更新日期：2016-10-28 00:00:00

abstract：:It is believed that subjects with high trait anxiety levels tend to present state anxiety reactions with greater intensity than individuals with low trait anxiety levels. In order to verify if this premise is valid for animal models of anxiety, the present work investigated the possible correlation between two behavio...

journal_title：Neuroscience letters

authors： Goes TC,Antunes FD,Teixeira-Silva F

更新日期：2009-02-06 00:00:00