Effect of adenosine versus adenine nucleotides on evoked potentials in a rat hippocampal slice preparation.

Abstract:

:A marked depression of evoked CA1 potentials was observed with the nucleotide analogues a,b-methylene ADP (AOPCP) and adenylimido-diphosphate (AIP) and with 2'-adenosine monophosphate (2'-AMP). While the depression elicited by 5'-nucleotides was completely antagonized by the action of adenosine deaminase, AOPCP and 2'-AMP were only partially antagonized. The findings indicate that nucleotides on their own are capable of modulating synaptic transmission but that the physiologically more prevalent 5'-AMP is mediating its effect via adenosine. By producing this membrane permeable compound and allowing its re-uptake, the 5'-nucleotidase may determine the time course of purinergic action.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lee KS,Schubert P,Emmert H,Kreutzberg GW

doi

10.1016/0304-3940(81)90016-1

subject

Has Abstract

pub_date

1981-05-29 00:00:00

pages

309-14

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(81)90016-1

journal_volume

23

pub_type

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