Abstract:
:Microglia, the resident immune cells of the brain, are activated in response to any kind of CNS injury, and their activation is critical for maintaining homeostasis within the CNS. However, during inflammatory conditions, sustained microglial activation results in damage to surrounding neuronal cells. beta-Glucans are widely recognized immunomodulators, but the molecular mechanisms underlying their immunomodulatory actions have not been fully explored. We previously reported that beta-glucans activate microglia through Dectin-1 without inducing significant amount of cytokines and chemokines. Here, we show that particulate beta-glucans attenuate cytokine production in response to TLR stimulation; this inhibitory activity of beta-glucan is mediated by Dectin-1 and does not require particle internalization. At the molecular level, beta-glucan suppressed TLR-mediated NF-kappaB activation, which may be responsible for the diminished capacity of microglia to produce cytokines in response to TLR stimulation. Overall, these results suggest that beta-glucans may be used to prevent or treat excessive microglial activation during chronic inflammatory conditions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shah VB,Williams DL,Keshvara Ldoi
10.1016/j.neulet.2009.04.039subject
Has Abstractpub_date
2009-07-24 00:00:00pages
111-5issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(09)00523-0journal_volume
458pub_type
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journal_title:Neuroscience letters
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