Abstract:
:L-Histidine decarboxylase catalyzes the formation of histamine from the amino acid L-histidine. We have studied the distribution of neurons expressing mRNA for histidine decarboxylase in adult rat brain using in situ hybridization with synthetic oligonucleotide probes. The expression of mRNA for histidine decarboxylase was detected in the hypothalamic tuberomammillary nucleus that has been shown to contain histidine decarboxylase-like and histamine-like immunoreactivity, but not in any other brain area. This method may prove useful in studying the physiological role of central histaminergic neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Castrén E,Panula Pdoi
10.1016/0304-3940(90)90181-8subject
Has Abstractpub_date
1990-11-27 00:00:00pages
113-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(90)90181-8journal_volume
120pub_type
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