Abstract:
:The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ito I,Okada D,Sugiyama Hdoi
10.1016/0304-3940(88)90808-7subject
Has Abstractpub_date
1988-07-19 00:00:00pages
181-5issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(88)90808-7journal_volume
90pub_type
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