Circadian rhythm in rat brain opiate receptor.

abstract：:The effect of prenatal ethanol exposure on the number of parvalbumin-immunoreactive (PA+) GABAergic neurons in the adult rat anterior cingulate cortex was determined. Pregnant Long-Evans rats were maintained on one of three diets throughout gestation: an ethanol-containing liquid diet, a similar, control liquid diet w...

journal_title：Neuroscience letters

authors： Moore DB,Quintero MA,Ruygrok AC,Walker DW,Heaton MB

更新日期：1998-06-12 00:00:00

abstract：:This study evaluates the neuroprotective properties of some voltage-sensitive sodium channel blockers in a model of focal ischaemia. After curative treatment (0.5 and 24.5 h after insult), well known voltage-sensitive sodium channel blockers, phenytoin (2 x 100 mg/kg i.p.), carbamazepine (2 x 50 mg/kg i.p.), lamotrigi...

journal_title：Neuroscience letters

authors： Rataud J,Debarnot F,Mary V,Pratt J,Stutzmann JM

更新日期：1994-05-19 00:00:00

abstract：:The acute thermoregulatory effect of microinjection of capsaicin into the nucleus raphe dorsalis (NRD) has been studied in anesthetised rats. Application of capsaicin (20 micrograms) into the NRD increased the tail skin temperature and decreased the body temperature. In animals that had previously been treated with ca...

journal_title：Neuroscience letters

authors： Hajós M,Hjorth S,Carlsson A

更新日期：1987-03-31 00:00:00

abstract：OBJECTIVES:To determine clinical characteristics and frequency of leucine-rich repeat kinase 2 gene (LRRK2) mutations in a cohort of patients with Parkinson's disease (PD) from Argentina. BACKGROUND:Variation in the LRRK2 gene represents the most common genetic determinant of PD, only few data are available from Latin...

journal_title：Neuroscience letters

authors： Gatto EM,Parisi V,Converso DP,Poderoso JJ,Carreras MC,Martí-Massó JF,Paisán-Ruiz C

更新日期：2013-03-14 00:00:00

abstract：:The role of the dorsal hippocampus in the different stages of blocking was examined in a taste aversion learning task. Blocking is a learning effect in which one previously conditioned element of a compound makes the conditioning of the added element difficult. An effective blocking procedure with one trial in each st...

journal_title：Neuroscience letters

authors： Gallo M,Cándido A

更新日期：1995-02-15 00:00:00

abstract：:The effects of systemic hypothermia (33.5 degrees C) on the ischemia-evoked release of the neurotransmitter amino acids, glutamate, aspartate, gamma-amino-butyric acid (GABA) and glycine into rat cerebral cortical superfusates were evaluated in the rat four vessel occlusion model. Glutamate, aspartate and GABA, but no...

journal_title：Neuroscience letters

authors： Simpson RE,Walter GA,Phillis JW

更新日期：1991-03-11 00:00:00

abstract：:Genetic polymorphism has been reported in the 3'-untranslated region (3'-UTR) of the human dopamine transporter (DAT) gene and the variable number of tandem repeat (VNTR) polymorphism has been proposed to be associated with normal personal traits or psychoneurological disorders. To assess the variation of this region ...

journal_title：Neuroscience letters

authors： Inoue-Murayama M,Adachi S,Mishima N,Mitani H,Takenaka O,Terao K,Hayasaka I,Ito S,Murayama Y

更新日期：2002-12-16 00:00:00

abstract：:The in vivo effects of the alpha 2-adrenoceptor idazoxan, rauwolscine and phentolamine on alpha 2-auto/heteroreceptors and 5-HT1A autoreceptors modulating the synthesis of dopa/noradrenaline and 5-HTP/serotonin were assessed in rats, using the accumulation of dopa and 5-HTP after decarboxylase inhibition as a measure ...

journal_title：Neuroscience letters

authors： Lladó J,Esteban S,García-Sevilla JA

更新日期：1996-11-01 00:00:00

abstract：:A critical component of the cellular stress response, the p53 tumor suppressor protein must be functional for many cancer therapies to be effective. Adjuvant therapies that augment p53 function are predicted to sensitize tumor cells to cancer therapies that rely upon p53 for their efficacy. Of those strategies current...

journal_title：Neuroscience letters

authors： Ghassemifar S,Mendrysa SM

更新日期：2012-03-28 00:00:00

abstract：:Cyclosporine A (CsA) is the major immunosuppressive drug used for organ and neural transplantation and the therapy of selected autoimmune diseases. We investigated the effect of CsA on the activity of acetylcholinesterase (AChE) in the frontal cortex, hippocampus, septum, and basal ganglia. AChE was determined spectro...

journal_title：Neuroscience letters

authors： Herink J,Krejcová G,Bajgar J,Svoboda Z,Kvĕtina J,Zivnú P,Palicka V

更新日期：2003-03-27 00:00:00

abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

journal_title：Neuroscience letters

authors： Compton RP,Hood WF,Monahan JB

更新日期：1988-02-03 00:00:00

abstract：:The soluble fraction of rat brain cortex yielded an antioxidant factor that inhibits the autoxidation of ascorbic acid at physiological pH. The measurements were based on spectrophotometric detection of ascorbic acid at 265 nm in a physiological salt solution of the Krebs-Ringer type, pH 7.4, or in sodium phosphate bu...

journal_title：Neuroscience letters

authors： Kovachich GB,Mishra OP

更新日期：1982-12-23 00:00:00

abstract：:Age-related impairment of learning and memory is a common phenomenon in humans and animals, yet the underlying mechanism remains unclear. We hypothesize that a small ubiquitin-related modifier (Sumo) might correlate with age-related loss of learning and memory. To test this hypothesis, the present study evaluated age-...

journal_title：Neuroscience letters

authors： Yang QG,Wang F,Zhang Q,Xu WR,Chen YP,Chen GH

更新日期：2012-06-19 00:00:00

abstract：:A pronounced decrease in dopamine content in both the striatum and the mesolimbic area was observed up to 120 days of age after treatment with 6-hydroxydopamine (100 micrograms, intracisternally) following desipramine pretreatment (20 mg/kg, i.p.) at the 5th postnatal day. In the 6-hydroxydopamine-treated rats, Met-en...

journal_title：Neuroscience letters

authors： Kurumaji A,Takashima M,Watanabe S,Takahashi K

更新日期：1988-04-22 00:00:00

abstract：:The insular cortex (IC) processes multimodal sensory information including gustatory, visceral, nociceptive, and thermal sensation, and is considered to play a role in the regulation of homeostasis. The IC receives dense histaminergic projection from the tuberomamillary nucleus in the hypothalamus, and recent studies ...

journal_title：Neuroscience letters

authors： Takei H,Song L,Ebihara K,Shirakawa T,Koshikawa N,Kobayashi M

更新日期：2012-06-14 00:00:00

abstract：:Prior animal studies have indicated that levels of oxidized glutathione (GSSG) in brain and other organs are low, comprising several percent, or less, of the total glutathione. An exception is seen in reports for autopsy and biopsy specimens of human brain, where very high levels of GSSG have been indicated. The latte...

journal_title：Neuroscience letters

authors： Slivka A,Spina MB,Cohen G

更新日期：1987-02-10 00:00:00

abstract：:To test the hypothesis that the expression of specific proteins on peripheral terminals of primary afferents can be attenuated by intrathecal administration of antisense oligodeoxynucleotides (ODNs), we administered ODNs antisense to the mu-opioid receptor to male Sprague-Dawley rats via chronically implanted intrathe...

journal_title：Neuroscience letters

authors： Khasar SG,Gold MS,Dastmalchi S,Levine JD

更新日期：1996-10-25 00:00:00

abstract：:Neuroblastoma is the most common extracranial pediatric solid tumor, arising from the embryonic sympathoadrenal lineage of the neural crest, and is responsible for 15% of childhood cancer deaths. Although survival rates are good for some patients, those children diagnosed with high-risk neuroblastoma have survival rat...

journal_title：Neuroscience letters

authors： Hegarty SV,Togher KL,O'Leary E,Solger F,Sullivan AM,O'Keeffe GW

更新日期：2017-07-13 00:00:00

abstract：:The intervibrissal fur-evoked activity in the rat somatosensory cortex was investigated using high-resolution optical imaging with a voltage-sensitive dye. The optical imaging revealed that the intervibrissal fur representation forms a U-shaped band around the borders of the posteromedial barrel subfield (PMBSF), and ...

journal_title：Neuroscience letters

authors： Takashima I,Kajiwara R,Iijima T

更新日期：2005-06-24 00:00:00

abstract：:A method is developed for PCR assay of mRNA using 28S rRNA as internal standard and its applicability is reported for 4 types of mRNA. It consists of reverse transcription of total RNA using primers selective for 28S rRNA and the message of interest. Routinely the 28S reaction mix is diluted 20,000-fold and the diluti...

journal_title：Neuroscience letters

authors： Khan I,Tabb T,Garfield RE,Grover AK

更新日期：1992-11-23 00:00:00

abstract：:During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5 degrees C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos in...

journal_title：Neuroscience letters

authors： Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TS

更新日期：1994-01-03 00:00:00

abstract：:Upregulation of cyclin-dependent kinase 5 (Cdk5) after chronic cocaine administration has led to speculation that Cdk5 plays an important role in drug addiction. However, as Cdk5 involvement is implicated in a variety of neural events, including neuronal development, synaptic plasticity and learning, a specific role i...

journal_title：Neuroscience letters

authors： Seiwell AP,Reveron ME,Duvauchelle CL

更新日期：2007-04-24 00:00:00

abstract：:Adult mouse sciatic nerves (SNs) with attached dorsal root ganglia (DRG) were analysed for the presence of mitogen activated protein kinase (MAP-K) during normal and regenerative conditions. By immunohistochemistry, MAP-K was found to be present in the normal nerve at low levels in both Schwann cells and DRG nerve cel...

journal_title：Neuroscience letters

authors： Svensson B,Ekström PA,Edström A

更新日期：1995-11-10 00:00:00

abstract：:Baclofen reduced the frequency and aborted the bursts of spontaneous paroxysmal discharges in rat neocortical slices maintained in magnesium-free medium. This action was prevented by pretreatment with barium or caesium, which each increased the ictaform burst frequency, amplitude and duration. 4-Amino-pyridine also in...

journal_title：Neuroscience letters

authors： Ong J,Kerr DI,Johnston GA

更新日期：1990-05-04 00:00:00

abstract：:Most of the phasically occurring periods of rapid eye movements (REMs) of active sleep are accompanied by enhanced suppression of somatomotor activity; however, during some of the REM episodes there are muscular twitches and jerks. The membrane potential changes underlying these motor processes were examined by record...

journal_title：Neuroscience letters

authors： Chase MH,Morales FR

更新日期：1982-12-30 00:00:00

abstract：:Chronic morphine administration induces neural plasticity followed by withdraw. And clinic observation indicates that obvious cognitive deficits are found during withdrawal. However, current neural substrates that regulate dysfunction in withdrawal are unknown. In our studies, chronic morphine administration was used ...

journal_title：Neuroscience letters

authors： Niu H,Zhang G,Li H,Zhang Q,Li T,Ding S,Wang L,Zhang Z,Qiao Y,Hu M

更新日期：2017-02-15 00:00:00

abstract：:The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides. These include anandamide, oleoyl ethanolamide and palmitoyl ethanolamide, and their effects are mediated by a variety of downstream targets including canna...

journal_title：Neuroscience letters

authors： Webb M,Luo L,Ma JY,Tham CS

更新日期：2008-07-04 00:00:00

abstract：:We previously reported that corticotropin-releasing factor (CRF) increased neuronal excitability specifically in type II neurons of the dorsolateral part of the bed nucleus of the stria terminalis (dlBNST). Because the majority of type II dlBNST neurons are thought to be GABAergic interneurons, at least a portion of w...

journal_title：Neuroscience letters

authors： Nagano Y,Kaneda K,Maruyama C,Ide S,Kato F,Minami M

更新日期：2015-07-23 00:00:00

abstract：:Interleukin-6 (IL-6) has been shown to have potent neurotrophic activity on peripheral and central neurons in vitro. However, it remains to be determined whether or not IL-6 rescues hippocampal CA1 neurons from lethal ischemia and prevents ischemia-induced learning disability. In the present in vivo study, we infused ...

journal_title：Neuroscience letters

authors： Matsuda S,Wen TC,Morita F,Otsuka H,Igase K,Yoshimura H,Sakanaka M

更新日期：1996-02-02 00:00:00

abstract：:Abnormalities of the white matter (WM) tracts integrity in brain areas involved in emotional regulation have been postulated in major depressive disorder (MDD). However, there is no diffusion tensor imaging (DTI) study in patients with treatment-responsive MDD at present. DTI scans were performed on 22 patients with t...

journal_title：Neuroscience letters

authors： Guo WB,Liu F,Xue ZM,Gao K,Wu RR,Ma CQ,Liu ZN,Xiao CQ,Chen HF,Zhao JP

更新日期：2012-08-01 00:00:00