Abstract:
:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for both the D-AP7 and D,L-AP7 are observed 10-15 min after i.v. administration and amount to approximately 0.1% of a 1 mmol/kg dose. Significant quantities (3 microM) are present in CSF at 2 h and no AP7 is detectable at 4 h. Following i.v. administration, a monoexponential clearance was observed for D-AP7 clearance from plasma, 15.4 +/- 0.8 S.E.M. ml/min/kg with a t1/2 of 38.9 +/- 0.8 S.E.M. min. However, a biexponential clearance from plasma was observed for D,L-AP7.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Compton RP,Hood WF,Monahan JBdoi
10.1016/0304-3940(88)90532-0subject
Has Abstractpub_date
1988-02-03 00:00:00pages
339-44issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(88)90532-0journal_volume
84pub_type
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