Abstract:
:Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highest local synchronization power, the most connected node, and the node with highest interactions load. Connectivity in the data is extracted from the Minimum Spanning Tree (MST) of global correlations. We address the question whether removal of these nodes during the surgery is crucial in the suppression or reduction in the quantity of post-operative seizures. From five ECoG records, local areas with high synchronization power appear to be significantly involved in the development of epileptic seizures. The other two areas seem not to be fundamental in the seizures onset and development. Moreover, the approach proposed shed new light in cortical connectivity patterns in the human temporal lobe. All the analyzed records are during the inter-ictal state.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ortega GJ,Sola RG,Pastor Jdoi
10.1016/j.neulet.2008.09.080subject
Has Abstractpub_date
2008-12-12 00:00:00pages
129-33issue
2-3eissn
0304-3940issn
1872-7972pii
S0304-3940(08)01330-Xjournal_volume
447pub_type
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