Abstract：
:Alpha-2 macroglobulin (encoded by the gene A2M) is a serum pan-protease inhibitor that may be related with the pathogenesis of Alzheimer's disease (AD) because of its ability to mediate amyloid beta degradation. Recently, several groups have reported that the five-nucleotides deletion in A2M gene at the 5' splice site of exon 18 might increase risk for AD. In the present study, therefore, this mutation was studied in 69 healthy controls and 55 sporadic AD cases by polymerase chain reaction- restriction fragment length polymorphism method. The allelic frequencies with the deletion (A2M-2) are 9.4 and 6.4% in the control and AD groups, respectively. There is no significant difference in the A2M-2 frequencies between the controls and sporadic AD cases. This is the first report to study the frequencies of A2M-2 in Japanese AD cases, suggesting its no genetic association with sporadic AD.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Arai Hdoi
10.1016/s0304-3940(99)00541-8keywords:
subject
Has Abstractpub_date
1999-08-20 00:00:00pages
132-4issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00541-8journal_volume
271pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Neuroscience letters
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