Abstract:
:Prolonged exposure of hippocampal slices to L-glutamate was found to produce a biphasic effect on excitatory synaptic transmission from Schaffer collateral-commissural fibers to CA1 pyramidal neurons: an early blockade of postsynaptic responses was followed by a progressive recovery. Antagonists of N-methyl-D-aspartate (NMDA) receptors, which had no effect on the initial responses, blocked the responses which reappeared during continued exposure to L-glutamate. Furthermore, when NMDA antagonists were maintained in the presence of glutamate, excitatory transmission was again restored and the new responses were now insensitive both to 'NMDA' and 'non-NMDA' antagonists. Once elicited, the changes in synaptic transmission appear to be 'memorized' by the slice for at least tens of minutes. These phenomena suggest that the well-known plasticity of the hippocampal synapses may involve a sequence of distinct 'states', and that transitions between these states can be induced by certain pharmacological stimuli.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Krishtal OA,Smirnov SV,Osipchuk YuVdoi
10.1016/0304-3940(88)90433-8subject
Has Abstractpub_date
1988-02-15 00:00:00pages
82-8issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(88)90433-8journal_volume
85pub_type
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