Abstract：
:Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of domestic and wild cervids in North America. To address possible prevention regimens for CWD, we have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential vaccine candidates. Three peptides derived from the primary amino acid sequence of the prion protein were conjugated to blue carrier protein (BCP) and formulated in an adjuvant containing M. avium subsp. avium. CL57/BL6 mice were vaccinated and boosted with 50 microg of the carrier protein-peptide conjugate formulation; all vaccines produced a humoral immune response as measured by ELISA. Disease challenge with the RML scrapie prion strain revealed anti-prion activity was generated by the vaccine formulations as measured by a delay in clinical disease onset and prolonged survivorship.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pilon J,Loiacono C,Okeson D,Lund S,Vercauteren K,Rhyan J,Miller Ldoi
10.1016/j.neulet.2007.10.015subject
Has Abstractpub_date
2007-12-18 00:00:00pages
161-4issue
2-3eissn
0304-3940issn
1872-7972pii
S0304-3940(07)01100-7journal_volume
429pub_type
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