Regional differences in the distribution of norepinephrine and epinephrine in human cerebral cortex: a neurochemical study using HPLC and electrochemical detection.

Abstract:

:We performed neurochemical quantitation of the catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) and their major metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in 22 cortical regions of 6 postmortem human brains. Statistical analysis indicated a clear regional difference for NE and E while DA and all the metabolites under study are homogeneously distributed over the cortex. These consistent regional differences suggest the possible role of NE and E as neurotransmitters or neuromodulators in human cerebral cortex.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Herregodts P,Michotte Y,Ebinger G

doi

10.1016/0304-3940(89)90422-9

subject

Has Abstract

pub_date

1989-04-10 00:00:00

pages

321-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90422-9

journal_volume

98

pub_type

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