Evaluation of tetrathiomolybdate in the R6/2 model of Huntington disease.

abstract：:The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration. Intra-NAc injection of the cyclic guanosine monop...

journal_title：Neuroscience letters

authors： Seo SY,Oh JH,Choe ES

更新日期：2013-06-07 00:00:00

abstract：:The existence of long-term effects of dark-rearing on visuo-motor coordination is still controversial. In this study 2 dark-reared (DR) cats were trained, after 5-6 years of recovery, to perform a reaching movement towards a stationary or a moving target. The accuracy, and the reaction and movement times were evaluate...

journal_title：Neuroscience letters

authors： Fabre-Thorpe M,Levesque F,Gary-Bobo E

更新日期：1990-10-16 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid plaques, neuritic degenerations, disturbed glutamatergic neurotransmission and a peculiar inflammatory response. Diffuse plaques develop into neuritic plaques when neurites undergo degeneration in the plaque area. Hyperphosphorylation of tau proteins is a major step...

journal_title：Neuroscience letters

authors： Hüll M,Eistetter J,Fiebich BL,Bauer J

更新日期：1999-02-12 00:00:00

abstract：:Intramural ganglia of colchicine-injected cat ileum were examined immunohistochemically using antisera to substance P (SP), vasoactive intestinal polypeptide (VIP) and methionine5-enkephalin (ENK). SP- and ENK-like immunoreactive nerve cells were preferentially located in the myenteric ganglia, whereas VIP-like immuno...

journal_title：Neuroscience letters

authors： Domoto T,Gonda T,Oki M,Yanaihara N

更新日期：1984-06-01 00:00:00

abstract：:The effect of various ionic solutions microinjected into the nucleus tractus solitarii (NTS) on blood pressure, heart rate and respiration rate was investigated in urethane-anesthetized rats. Unilateral microinjection of solutions containing NaCl (154 mM), NaCl (154 mM) and KCl (2.8 mM) or NaNO3 (154 mM) into a restri...

journal_title：Neuroscience letters

authors： Lukovic L,de Jong W

更新日期：1990-03-02 00:00:00

abstract：:To test if nitric oxide (NO) is involved in modulation of neuronal activity after global changes of brain function, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) reactivity in the cerebellar cortex was compared in monkeys maintained under anaesthesia for 24-48 h with others only anaesthetised for pe...

journal_title：Neuroscience letters

authors： Yan XX,Garey LJ

更新日期：1997-07-18 00:00:00

abstract：:At postnatal day (PN)1, there are sex differences in gonadal receptor expression in the rat substantia nigra pars reticulata (SNR). Male pups have lower levels of androgen receptor (AR) and estrogen receptor (ER)beta immunoreactivity (IR) compared to female pups, while ERalpha IR is equally expressed in the two sexes....

journal_title：Neuroscience letters

authors： Ravizza T,Velísková J,Moshé SL

更新日期：2003-02-20 00:00:00

abstract：:When standing quietly, human upright stance is typically approximated as a single segment inverted pendulum. In contrast, investigations which perturb upright stance with support surface translations or visual driving stimuli have shown that the body behaves like a two-segment pendulum, displaying both in-phase and an...

journal_title：Neuroscience letters

authors： Creath R,Kiemel T,Horak F,Peterka R,Jeka J

更新日期：2005-03-29 00:00:00

abstract：:In control samples, intense acoustic "go" stimuli accelerate the central and peripheral motor processes that compose simple reaction time movements. The goal of the current study was to determine whether movements that are initiated to intense acoustic cues facilitate simple reaction times in (1) adults with chronic s...

journal_title：Neuroscience letters

authors： Coombes SA,Janelle CM,Cauraugh JH

更新日期：2009-03-13 00:00:00

abstract：:Bradykinin, an inflammatory mediator produced from plasma kallikreins, has potent effects on vascular functions, including increasing plasma extravasation and vasodilation. Attenuation in the response (desensitization to maintained exposure or tachyphylaxis to repeated administration) to bradykinin actions on synovial...

journal_title：Neuroscience letters

authors： Miao FJ,Khasar SG,Green PG,Levine JD

更新日期：1996-04-19 00:00:00

abstract：:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1...

journal_title：Neuroscience letters

authors： Perrin RJ,Payton JE,Barnett DH,Wraight CL,Woods WS,Ye L,George JM

更新日期：2003-10-02 00:00:00

abstract：:Mere observation of objects in our surroundings can potentiate movement, a fact reflected by visually-primed activation of motor cortical networks. This mechanism holds potential value for reactive balance control where recovery actions of the arms or legs must be targeted to a new support base to avoid a fall. The pr...

journal_title：Neuroscience letters

authors： McDannald DW,Mansour M,Rydalch G,Bolton DAE

更新日期：2018-09-14 00:00:00

abstract：:This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

journal_title：Neuroscience letters

authors： Motl RW,Knowles BD,Dishman RK

更新日期：2003-08-21 00:00:00

abstract：:The perception of visual motion is dependent on a set of occipitotemporal regions that are readily accessible to neuromodulation. The current study tested if paired-pulse Transcranial Magnetic Stimulation (ppTMS) could modulate motion perception by stimulating the occipital cortex as participants viewed near-threshold...

journal_title：Neuroscience letters

authors： Gamboa OL,Brito A,Abzug Z,D'Arbeloff T,Beynel L,Wing EA,Dannhauer M,Palmer H,Hilbig SA,Crowell CA,Liu S,Donaldson R,Cabeza R,Davis SW,Peterchev AV,Sommer MA,Appelbaum LG

更新日期：2020-06-21 00:00:00

abstract：:This study assessed the effect of the kappa opioid receptor agonist U50,488 administered into the rat temporomandibular joint (TMJ) on nociceptive behavioral responses evoked by formalin injected into the same site. Groups consisted of females, stratified into proestrus and diestrus phases of the estrous cycle, and ma...

journal_title：Neuroscience letters

authors： Clemente JT,Parada CA,Veiga MC,Gear RW,Tambeli CH

更新日期：2004-12-06 00:00:00

abstract：:Specific (nerve growth factor, NGF) and non-specific (serum albumin, BSA) uptake followed by retrograde axonal transport was studied in the sciatic nerves of normal (C57BL/6J) and dystrophic (dy2J/dy2J) mice. In the dystrophic mouse there was a significant decrease in the amount of NGF transported to dorsal root gangl...

journal_title：Neuroscience letters

authors： Rutherford PS,Boegman RJ

更新日期：1982-12-31 00:00:00

abstract：:The axonal efferents of neurons of the supraoptic nucleus area were studied by radioautography in the rat after discrete stereotaxic injections of [3H]leucine into this nucleus. Beside a densely labeled pathway running from the nucleus to the posterior pituitary through the internal median eminence, several of the vis...

journal_title：Neuroscience letters

authors： Alonso G,Szafarczyk A,Assenmacher I

更新日期：1986-05-23 00:00:00

abstract：:The rodent gustatory cortex is located in the anterior part of the insular cortex, which is near the dorsal part of the rhinal vein (RHV) and the intersection of the anterior and posterior regions of the middle cerebral artery (MCA). Thus, the intersection between the RHV and MCA is used as a landmark for the rodent g...

journal_title：Neuroscience letters

authors： Kida I,Enmi J,Iida H,Yoshioka Y

更新日期：2015-03-04 00:00:00

abstract：:Optic fibre regeneration in young Xenopus was studied by [(3)H]proline autoradiography and by mapping the visuotectal projection electrophysiologically from 5 to 210 days after sectioning the right optic nerve. Regenerated optic fibers were demonstrated morphologically both in the contra and ipsilateral tecta. In cont...

journal_title：Neuroscience letters

authors： Glastonbury J,Straznicky K

更新日期：1978-01-01 00:00:00

abstract：:As interest in the gut microbiome has grown in recent years, attention has turned to the impact of our diet on our brain. The benefits of a high fiber diet in the colon have been well documented in epidemiological studies, but its potential impact on the brain has largely been understudied. Here, we will review eviden...

journal_title：Neuroscience letters

authors： Bourassa MW,Alim I,Bultman SJ,Ratan RR

更新日期：2016-06-20 00:00:00

abstract：:After systemic administration of the dopamine agonist apomorphine (APO) in common toads Bufo bufo spinosus, the excitatory receptive fields of retinal R2 and R3 ganglion cells doubled their size and the response activities of these neurons to moving visual stimuli were generally increased. Comparable investigations of...

journal_title：Neuroscience letters

authors： Glagow M,Ewert JP

更新日期：1994-05-23 00:00:00

abstract：:The main purpose of the present paper was: (1) to study the phase synchronization pattern in the gamma-band while performing the classical Shepard-Metzler task of mental rotation; (2) to investigate the role of musical training; and (3) to study hemispheric differences in the degree of synchronization during mental ro...

journal_title：Neuroscience letters

authors： Bhattacharya J,Petsche H,Feldmann U,Rescher B

更新日期：2001-09-21 00:00:00

abstract：:Mutations in coding exons or exon 10 5'-splice-site of the gene for microtubule-associated protein tau can cause chromosome 17-linked frontotemporal dementia and parkinsonism (FTDP-17). We sequenced the 11 coding exons plus exon-intron boundaries of the tau gene in 15 cases of progressive supranuclear palsy (PSP), and...

journal_title：Neuroscience letters

authors： Bonifati V,Joosse M,Nicholl DJ,Vanacore N,Bennett P,Rizzu P,Fabbrini G,Marconi R,Colosimo C,Locuratolo N,Stocchi F,Bonuccelli U,De Mari M,Wenning G,Vieregge P,Oostra B,Meco G,Heutink P

更新日期：1999-10-15 00:00:00

abstract：:Suicide is a major contributor to the morbidity and mortality of schizophrenia, accounting for approximately 10% of deaths in these patients. Genetic factors have been reported to modulate the risk for suicide, although the precise mechanism and magnitude of the genetic contribution are unknown. Further, suicide attem...

journal_title：Neuroscience letters

authors： Souza RP,De Luca V,Manchia M,Kennedy JL

更新日期：2011-02-11 00:00:00

abstract：BACKGROUND:Studies have demonstrated that the failure of oligodendrocyte precursor cells (OPCs) differentiation as a major cause of remyelination failure in demyelinating disease. The reasons for this failure are not completely understood. We hypothesized that the present of myelin debris in CNS play an important role ...

journal_title：Neuroscience letters

authors： Liu Q,Lv HW,Yang S,He YQ,Ma QR,Liu J

更新日期：2020-04-23 00:00:00

abstract：:The aim of this study was to investigate the relationship between the functional C957T single-nucleotide polymorphism of the dopamine D2 receptor (DRD2) gene and the risk for schizophrenia. We therefore conducted a case-control association study of 188 Finnish schizophrenia patients meeting the DSM-IV criteria and 384...

journal_title：Neuroscience letters

authors： Hänninen K,Katila H,Kampman O,Anttila S,Illi A,Rontu R,Mattila KM,Hietala J,Hurme M,Leinonen E,Lehtimäki T

更新日期：2006-10-30 00:00:00

abstract：:The present study was carried out to examine whether γ-aminobutyric acid (GABA) receptor mechanisms are involved in the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) using intracerebral microdialysis techniques. Perfusion with the GABA receptor antagonists as well as agonists was perf...

journal_title：Neuroscience letters

authors： Takahashi M,Nomura M,Tanaka J

更新日期：2016-09-06 00:00:00

abstract：:In lateral line and electrosensory systems of fish, the animal's own movements create unwanted stimulation that could interfere with the detection of biologically important signals. Here we report that an adaptive filter in the medullary nuclei of both senses suppresses self-stimulation. Second-order electrosensory ne...

journal_title：Neuroscience letters

authors： Montgomery JC,Bodznick D

更新日期：1994-06-20 00:00:00

abstract：:Using frozen-thawed and extensively washed rat cortical membranes, the effects of 3-((+/-)2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) on [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) binding stimulated by either 1 microM L-glutamate or 300 microM Mg2+ were examined. CPP much more potently inhibit...

journal_title：Neuroscience letters

authors： Hatta K,Yamamato T,Hori T,Okuwa M,Moroji T

更新日期：1991-04-01 00:00:00

abstract：:This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeO...

journal_title：Neuroscience letters

authors： Nabeshima T,Ishikawa K,Yamaguchi K,Furukawa H,Kameyama T

更新日期：1987-05-19 00:00:00