Abstract:
:The aim of this study was to investigate the relationship between the functional C957T single-nucleotide polymorphism of the dopamine D2 receptor (DRD2) gene and the risk for schizophrenia. We therefore conducted a case-control association study of 188 Finnish schizophrenia patients meeting the DSM-IV criteria and 384 healthy controls. The 5' nuclease assay (TaqMan) was used to determine genotypes. A greater proportion of patients with schizophrenia than healthy controls were C-allele carriers (odds ratio 1.5, 95% confidence interval (CI) 1.0-2.3, P=0.05). Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hänninen K,Katila H,Kampman O,Anttila S,Illi A,Rontu R,Mattila KM,Hietala J,Hurme M,Leinonen E,Lehtimäki Tdoi
10.1016/j.neulet.2006.08.041subject
Has Abstractpub_date
2006-10-30 00:00:00pages
195-8issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(06)00862-7journal_volume
407pub_type
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