Abstract:
:Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected cell lines, rat C-6 glioma, human primary glioma and mouse teratocarcinoma, expressed an increased level of MHC-I and of co-signaling B-7 molecules. This increased expression of MHC-I and B-7, demonstrated by 51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Trojan J,Duc HT,Upegui-Gonzalez LC,Hor F,Guo Y,Anthony D,Ilan Jdoi
10.1016/0304-3940(96)12770-1subject
Has Abstractpub_date
1996-07-05 00:00:00pages
9-12issue
1eissn
0304-3940issn
1872-7972pii
0304394096127701journal_volume
212pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章,评审
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.134415
更新日期:2019-10-15 00:00:00
abstract::The reactivity of different narrow electroencephalographic (EEG) frequencies (4-6, 6-8, 8-10 and 10-12 Hz) to three types of emotionally laden film clips (aggressive, sad, neutral) were examined. We observed that different EEG frequency bands responded differently to the three types of film content. In the 4-6 Hz freq...
journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.10.103
更新日期:2009-01-09 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:2002-10-25 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.01.039
更新日期:2010-03-08 00:00:00
abstract::Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia. Administered as pretreatment, diazoxide can attenuate ischemia-related neuronal injury, but little is known about the potential neuroprotective properties of the drug when it ...
journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2005-10-28 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.02.035
更新日期:2007-04-24 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.03.020
更新日期:2006-06-19 00:00:00
abstract::Rats become susceptible to audiogenic seizures (AS) when they are exposed to intense noise during a certain critical period of development (priming). Antagonism of N-methyl-D-aspartate (NMDA) receptor NR2B subunit by injecting an antagonist ifenprodil at priming enhanced the later susceptibility to AS. An weak NR2A an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01219-2
更新日期:2000-07-14 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(79)95341-2
更新日期:1979-09-01 00:00:00