Presence of MHC-I and B-7 molecules in rat and human glioma cells expressing antisense IGF-I mRNA.

Abstract:

:Tumor cells frequently express the insulin-like growth factor I (IGF-I). Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I cDNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we show that the cultured transfected cell lines, rat C-6 glioma, human primary glioma and mouse teratocarcinoma, expressed an increased level of MHC-I and of co-signaling B-7 molecules. This increased expression of MHC-I and B-7, demonstrated by 51Cr release complement dependent cytoxicity assay and by immunostaining flow cytometry analysis, could contribute to the final immune recognition of glioma immunogenicity.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Trojan J,Duc HT,Upegui-Gonzalez LC,Hor F,Guo Y,Anthony D,Ilan J

doi

10.1016/0304-3940(96)12770-1

subject

Has Abstract

pub_date

1996-07-05 00:00:00

pages

9-12

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304394096127701

journal_volume

212

pub_type

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