Effects of N-methyl-D-aspartate receptor subunit antagonists on regulation of susceptibility to audiogenic seizures in rats.

abstract：:Recent evidence has suggested that down-regulation of somatostatin (SST) expression in the human brain during early stages of aging leads to an elevation in the steady-state levels of Abeta and therefore may be involved in Alzheimer's disease (AD) progression. We hypothesized that alterations in the SST gene might alt...

journal_title：Neuroscience letters

authors： Xue S,Jia L,Jia J

更新日期：2009-11-13 00:00:00

abstract：:Activation of microglia is a central part of the chronic inflammatory process in Alzheimer disease (AD). The monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a role in microglial migration and accumulation at sites of beta-amyloid deposition in senile plaques in the AD brain. A polymorphism in the ...

journal_title：Neuroscience letters

authors： Combarros O,Infante J,Llorca J,Berciano J

更新日期：2004-04-22 00:00:00

abstract：:We measured levels of basal and norepinephrine (NE) -induced melatonin release in cultured pineal bodies of rats just after and 2 days after irradiation (20 or 200 Gy) or sham-irradiation. On the day of irradiation, basal and NE-induced melatonin release were not affected by irradiation. Two days after irradiation, ba...

journal_title：Neuroscience letters

authors： Saito K,Shinohara K,Morofushi M,Funabashi T,Mitsushima D,Hata M,Matsubara S,Kimura F

更新日期：2000-04-21 00:00:00

abstract：:The effects of i.v. administration of a nitric oxide (NO) synthase inhibitor, L-NG-nitroarginine (L-NOArg), on the increase in cerebral cortical blood flow (cortical BF), following either electrical stimulation of the nucleus basalis of Meynert (NBM), whose cholinergic fibers project to the cortex, or hypercapnia with...

journal_title：Neuroscience letters

authors： Adachi T,Inanami O,Sato A

更新日期：1992-05-25 00:00:00

abstract：:Neuroblastoma is the most common extracranial pediatric solid tumor, arising from the embryonic sympathoadrenal lineage of the neural crest, and is responsible for 15% of childhood cancer deaths. Although survival rates are good for some patients, those children diagnosed with high-risk neuroblastoma have survival rat...

journal_title：Neuroscience letters

authors： Hegarty SV,Togher KL,O'Leary E,Solger F,Sullivan AM,O'Keeffe GW

更新日期：2017-07-13 00:00:00

abstract：:The effect of different frequencies of music on brain function was investigated through measurement of blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that exposure to Mozart's music (K. 205) leads to increased calcium/calmodulin-dependent dopamine synthesis in the brain, and that t...

journal_title：Neuroscience letters

authors： Akiyama K,Sutoo D

更新日期：2011-01-03 00:00:00

abstract：:Occurring at rates up to 6-7 syllables per second, speech perception and understanding involves rapid identification of speech sounds and pre-activation of morphemes and words. Using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the time-course and neural sources of ...

journal_title：Neuroscience letters

authors： Roll M,Söderström P,Frid J,Mannfolk P,Horne M

更新日期：2017-09-29 00:00:00

abstract：:Bisphenol-A (BPA), a toxic chemical from polycarbonate plastics, is known for behavioural and neural abnormalities. These neuro-behavioural changes reflect the changes in neural activity. However the effect of BPA on nerve action potential is not available. Therefore, present investigation was undertaken to study the ...

journal_title：Neuroscience letters

authors： Pandey AK,Deshpande SB

更新日期：2012-05-31 00:00:00

abstract：:Interleukin-6 (IL-6) has been shown to have potent neurotrophic activity on peripheral and central neurons in vitro. However, it remains to be determined whether or not IL-6 rescues hippocampal CA1 neurons from lethal ischemia and prevents ischemia-induced learning disability. In the present in vivo study, we infused ...

journal_title：Neuroscience letters

authors： Matsuda S,Wen TC,Morita F,Otsuka H,Igase K,Yoshimura H,Sakanaka M

更新日期：1996-02-02 00:00:00

abstract：:The effects of administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (O-DH-PC), a kind of lecithin, and of glycerophosphorylcholine (GPC) on sleep were investigated in male F344 rats. Intracerebroventricular administration of O-DH-PC at a dose of 10 micrograms/rat induced significant increase in ...

journal_title：Neuroscience letters

authors： Hashimoto M,Gong XW,Izaki Y,Iriki M,Hibino H

更新日期：1993-08-06 00:00:00

abstract：:The kynurenine pathway converts tryptophan into various compounds, including L-kynurenine, which in turn can be converted to the excitatory amino acid receptor antagonist kynurenic acid. The hypothesis that endogenously-produced kynurenic acid could have physiological effects was tested in combined entorhinal/hippocam...

journal_title：Neuroscience letters

authors： Scharfman HE,Ofer A

更新日期：1997-03-14 00:00:00

abstract：:Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists. The Fmr1 knockout (KO) mouse has been found to be a ...

journal_title：Neuroscience letters

authors： Wrenn CC,Heitzer AM,Roth AK,Nawrocki L,Valdovinos MG

更新日期：2015-01-12 00:00:00

abstract：:We have previously shown that P7 rat pups injected with the N-methyl-d-aspartate receptor (NMDAR) blocker MK801 displayed robust apoptotic injury within hours after injection. Further studies from our lab suggest that loss of calcium cannot be compensated for when vulnerable neurons lack calcium buffering capabilities...

journal_title：Neuroscience letters

authors： Turner CP,Debenedetto D,Liu C

更新日期：2009-02-06 00:00:00

abstract：:The ability of three nitric oxide (NO) donor compounds to modify ligand binding to kainate receptors was studied in tissue from human adult autopsy brains. Binding of [3H]kainic acid (5 nM) was measured in frontal cortex membranes made from Brodmann area 8 (BA 8) and autoradiographically using sections of frontal cort...

journal_title：Neuroscience letters

authors： Lees RD,Slater P,D'Souza SW

更新日期：1997-09-19 00:00:00

abstract：:The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found during various goal...

journal_title：Neuroscience letters

authors： Zhou Y,Liang M,Jiang T,Tian L,Liu Y,Liu Z,Liu H,Kuang F

更新日期：2007-05-07 00:00:00

abstract：:The efficacy of beta 1-adrenoceptor-G protein coupling was studied in postmortem temporal cortex synaptic membranes from a series of control and Alzheimer's disease subjects. For the control cases, the non-hydrolysable GTP analogue 5'-guanylylimidodiphosphate (Gpp[NH]p) gave a significant reduction in the affinity of ...

journal_title：Neuroscience letters

authors： Cowburn RF,Vestling M,Fowler CJ,Ravid R,Winblad B,O'Neill C

更新日期：1993-06-11 00:00:00

abstract：:In our horseradish peroxidase (HRP) study of the afferents to the medullary raphe nuclei in the cat, HRP uptake by damaged axons en route to the inferior olive (IO) was thought to be responsible for retrograde labelling of specific midbrain nuclei. To control for such indirect labelling, HRP was injected iontophoretic...

journal_title：Neuroscience letters

authors： Abols IA,Basbaum AI

更新日期：1979-07-01 00:00:00

abstract：:Dissociable circadian rhythms of sleep and body temperature in primates are thought to be regulated by independent oscillators whereas the uncoupling of circadian rhythms has not been well described in other mammals. Therefore, we made simultaneous recordings of non-rapid-eye-movement-sleep (NREMS), rapid-eye-movement...

journal_title：Neuroscience letters

authors： Ikeda M,Sagara M,Inoué S

更新日期：2000-02-04 00:00:00

abstract：:[3H]Nitrendipine bound to cerebral cortex membranes is displaced more efficiently by verapamil in old rats (24 months old) compared to young ones (3 months old). In addition, [3H]verapamil binding was studied in detail in 3-, 12- and 24-month-old rats. Aging increases the Bmax of [3H]verapamil, leaving the affinity un...

journal_title：Neuroscience letters

authors： Battaini F,Govoni S,Rius RA,Trabucchi M

更新日期：1985-10-24 00:00:00

abstract：:Adenosine and AMP (5'-adenosine monophosphate) applied by microiontophoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline response...

journal_title：Neuroscience letters

authors： Stone TW,Taylor DA

更新日期：1979-01-01 00:00:00

abstract：:In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied ...

journal_title：Neuroscience letters

authors： Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJ

更新日期：1991-08-05 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG) is a powerful antioxidant with suggested neuroprotective action. This study investigated the protective effects of EGCG against retinal ganglion cells (RGCs) degeneration in an animal model of glaucoma. C57BL/6J mice (n=54) were divided randomly into four groups: normal control group ...

journal_title：Neuroscience letters

authors： Shen C,Chen L,Jiang L,Lai TY

更新日期：2015-07-23 00:00:00

abstract：:Purinoceptor agonists produced potassium currents with the order of potency: ATP > adenosine = ADP = AMP > beta,gamma-methylene ATP, while a small response or no response was induced by 2-methylthio ATP, UTP, or alpha,beta-methylene ATP. The response induced by beta,gamma-methylene ATP was completely inhibited in the ...

journal_title：Neuroscience letters

authors： Matsuoka T,Nishizaki T,Nomura T,Mori M,Okada Y

更新日期：1998-05-29 00:00:00

abstract：:This study investigates whether potassium ion (K+) channels are involved in the nitric oxide (NO)-induced relaxation in segments of the isolated rat basilar artery, mounted onto a wire myograph. A high extracellular K+ concentration partly inhibited the relaxant effects of the NO donors DEA/NO and SIN-1 (3-morpholino-...

journal_title：Neuroscience letters

authors： Hempelmann RG,Seebeck J,Kruse ML,Ziegler A,Mehdorn HM

更新日期：2001-11-02 00:00:00

abstract：:Convulsions were induced in rats by a single injection of pentylenetetrazol (PTZ) and [3H]L-2-amino-4-phosphonobutyrate ([3H]L-AP4) in vitro receptor autoradiography was used to evaluate the effects on the expression of group III metabotropic glutamate receptors. Significant increases by 60-80% in [3H]L-AP4 binding wa...

journal_title：Neuroscience letters

authors： Thomsen C

更新日期：1999-04-30 00:00:00

abstract：:Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder in children and adults. Its similarity to other psychostimulants suggests that, at certain doses, the drug may generate lasting neuroadaptations that can be detrim...

journal_title：Neuroscience letters

authors： Taukulis HK,Bigney EE,Fry MD,Hooper C

更新日期：2014-04-30 00:00:00

abstract：:Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin on prosta...

journal_title：Neuroscience letters

authors： Tringali G,Vairano M,Dello Russo C,Preziosi P,Navarra P

更新日期：2004-01-09 00:00:00

abstract：:Opioids are used in clinical practice to relieve moderate to severe pain. Prolonged use of opioids can lead to a situation of analgesic tolerance and dependence. Several mechanisms are involved in the tolerance to analgesic opioids, including desensitization or internalization of the opioid receptor, elevation of cAMP...

journal_title：Neuroscience letters

authors： Shirooie S,Esmaeili J,Sureda A,Esmaeili N,Mirzaee Saffari P,Yousefi-Manesh H,Dehpour AR

更新日期：2020-01-18 00:00:00

abstract：:We are constantly exposed to symbols such as traffic signs, emoticons in internet communication, or other abstract representations of objects as well as, of course, the written words. However, aside from the word reading, little is known about the way our brain responds when we read non-lexical iconic symbols. By usin...

journal_title：Neuroscience letters

authors： Shin YW,Kwon JS,Kwon KW,Gu BM,Song IC,Na DG,Park S

更新日期：2008-05-16 00:00:00

abstract：:The circadian modulation of occurrence of non-rapid-eye-movement sleep (NREM) was investigated in 37 volunteers under dim-light conditions after 24-h total sleep deprivation using a 26-h 10/20-min ultra-short sleep-wake schedule. The propensity of NREM showed rapid increase followed by gradual decrease during the subj...

journal_title：Neuroscience letters

authors： Tagaya H,Uchiyama M,Shibui K,Kim K,Suzuki H,Kamei Y,Okawa M

更新日期：2002-04-19 00:00:00