Abstract:
:In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied by declines of extracellular free calcium concentration and were suppressed by the organic calcium antagonists verapamil and flunarizine. PD-like fluctuations of the membrane potential could be evoked also in CA3 neurons functionally isolated by tetrodotoxin (TTX). The observations indicate that caffeine-induced PD are generated endogenously and that transmembranous calcium currents contribute to these mechanisms.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJdoi
10.1016/0304-3940(91)90718-9subject
Has Abstractpub_date
1991-08-05 00:00:00pages
51-4issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(91)90718-9journal_volume
129pub_type
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