Tetrodotoxin-sensitive persistent current boosts the depolarization of retinal amacrine cells in goldfish.

abstract：:Muscle and cutaneous nerves were individually labeled with DiI in chick embryos to examine the development of sensory afferent arborizations in the spinal cord. Initially, cutaneous and muscle arbors were similar; both types first entered the spinal gray matter at stage 28-29 (embryonic day (E) 6). Differences in proj...

journal_title：Neuroscience letters

authors： Mendelson B,Koerber HR,Frank E

更新日期：1992-04-13 00:00:00

abstract：:The recurrence of dopamine-immunoreactive (DAi) fibers and the effect of the adrenocorticotrophic hormone (ACTH)-(4-9) analog ORG 2766 on this process were investigated 1, 4, 12 and 24 weeks after a unilateral 6-hydroxydopamine (6-OHDA) lesion in the nucleus accumbens (NAc). DAi fibers were almost completely absent 1 ...

journal_title：Neuroscience letters

authors： Vos PE,Steinbusch HW,Van Ree JM

更新日期：1996-03-22 00:00:00

abstract：:Superfusion of the isolated spinal cord of neonatal rats (4-9 days postpartum) with physiological medium containing 2-chloroadenosine (2-CA) or anoxic medium (equilibrated with 95% N2-5% CO2) depressed the evoked monosynaptic reflex (MSR) recorded extracellularly from a ventral spinal root. The effectiveness of 2-CA o...

journal_title：Neuroscience letters

authors： Lloyd HG,Perkins A,Spence I

更新日期：1989-06-19 00:00:00

abstract：:Recent studies have shown that PLA2G6 is a causative gene for PARK14-linked autosomal recessive early-onset complicated dystonia-parkinsonism, early-onset parkinsonism with frontotemporal dementia and autosomal recessive early-onset Parkinsonism without added complicated clinical features. In order to investigate the ...

journal_title：Neuroscience letters

authors： Tian JY,Tang BS,Shi CH,Lv ZY,Li K,Yu RL,Shen L,Yan XX,Guo JF

更新日期：2012-04-18 00:00:00

abstract：:The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...

journal_title：Neuroscience letters

authors： McCartney AM,Abejuela VL,Isaacson LG

更新日期：2008-08-01 00:00:00

abstract：:New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5...

journal_title：Neuroscience letters

authors： Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SK

更新日期：2018-05-29 00:00:00

abstract：:Amphiphilic monomers and dimers of acetylcholinesterase (AChE) and hydrophilic tetramers of butyrylcholinesterase (BuChE) were released by extracting human meningioma with Tris-saline and Tris-saline-Triton X-100 buffers. The amphiphilic or hydrophilic behavior of the AChE and BuChE forms was assessed by sedimentation...

journal_title：Neuroscience letters

authors： Sáez-Valero J,Vidal CJ

更新日期：1995-08-04 00:00:00

abstract：:Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we invest...

journal_title：Neuroscience letters

authors： Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai H

更新日期：2000-08-25 00:00:00

abstract：:The somatosensory homunculus has been identified during stimulation of median (at wrist and elbow), femoral, tibial and pudendal nerves of the left hemibody via the neuromagnetic imaging technique. The somatic representations of different body districts have been localized in the somatosensory cortex, by means of an e...

journal_title：Neuroscience letters

authors： Narici L,Modena I,Opsomer RJ,Pizzella V,Romani GL,Torrioli G,Traversa R,Rossini PM

更新日期：1991-01-02 00:00:00

abstract：:Although abnormal processing of amyloid precursor protein (APP) leads to early onset of Alzheimer's disease, the normal function of this protein is poorly understood. APP is widely expressed in axons, dendrites, and synapses in both central and peripheral nervous systems. Mice homozygous for APP or its homologue APP-l...

journal_title：Neuroscience letters

authors： Yang G,Gong YD,Gong K,Jiang WL,Kwon E,Wang P,Zheng H,Zhang XF,Gan WB,Zhao NM

更新日期：2005-08-12 00:00:00

abstract：:Antipsychotic drugs remain the mainstay of pharmacotherapy for schizophrenia. As there are large individual variations in efficacy and side-effects of antipsychotic drugs, there is a strong demand for personalized medication to treat schizophrenia. Pharmacogenetic research into antipsychotic drugs has examined a numbe...

journal_title：Neuroscience letters

authors： Han M,Deng C

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinfl...

journal_title：Neuroscience letters

authors： Hounie AG,Cappi C,Cordeiro Q,Sampaio AS,Moraes I,Rosário MC,Palácios SA,Goldberg AC,Vallada HP,Machado-Lima A,Nakano E,Kalil J,Pauls D,Pereira CA,Guilherme L,Miguel EC

更新日期：2008-09-12 00:00:00

abstract：:Acrolein-induced oxidative stress is hypothesized to involve in the etiology of Alzheimer's disease (AD). Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) have antioxidative and neuroprotective properties. The present study investigated the protective effects of CA/CAPE on acrolein-induced oxidative neuronal ...

journal_title：Neuroscience letters

authors： Huang Y,Jin M,Pi R,Zhang J,Chen M,Ouyang Y,Liu A,Chao X,Liu P,Liu J,Ramassamy C,Qin J

更新日期：2013-02-22 00:00:00

abstract：:We assessed whether tolerance develops to the antinociceptive effect of intrathecal (i.t.) orphanin FQ, the endogenous ligand of the orphan opioid-like receptor, and whether there is a cross-tolerance between the antinociceptive effect of i.t. orphanin FQ and the mu opioid receptor agonist morphine. Orphanin FQ admini...

journal_title：Neuroscience letters

authors： Hao JX,Wiesenfeld-Hallin Z,Xu XJ

更新日期：1997-02-14 00:00:00

abstract：:Small iontophoretic applications of wheat germ agglutinin-conjugated to horseradish peroxidase have been used to simultaneously observe, in the rat, the afferent and efferent connections of small parabrachial subregions in the same animal. The results demonstrate that a restricted region centered on the external porti...

journal_title：Neuroscience letters

authors： Bernard JF,Peschanski M,Besson JM

更新日期：1989-05-22 00:00:00

abstract：:Compared to other M(1) muscarinic acetylcholine receptor (M(1) mAChR) agonists, xanomeline demonstrates both reversible and persistent modes of binding to the receptor. In our study, we investigated the long-term consequences of brief incubation of Chinese hamster ovary cells expressing M(1) mAChR (M(1)-CHO) with low ...

journal_title：Neuroscience letters

authors： De Lorme KC,Sikorski KL,Grant MK,El-Fakahany EE

更新日期：2006-12-13 00:00:00

abstract：:Dysregulated brain glucose metabolism and lactate accumulation are seen following traumatic brain injury (TBI). The underlying molecular mechanism is poorly understood. Pyruvate dehydrogenase (PDH), the rate-limiting enzyme coupling cytosolic glycolysis to mitochondrial citric acid cycle, plays a critical role in main...

journal_title：Neuroscience letters

authors： Xing G,Ren M,Watson WD,O'Neill JT,Verma A

更新日期：2009-04-17 00:00:00

abstract：:Recent evidence suggests a predominant role for potassium (K) efflux in apoptotic cell death yet there exists controversy as to the exact nature of this involvement of K. In the present study we tested the anti-apoptotic efficacy of K channel blockers, tetraethylammonium Cl (TEA), and high extracellular K, the sodium ...

journal_title：Neuroscience letters

authors： Small DL,Tauskela J,Xia Z

更新日期：2002-12-13 00:00:00

abstract：:The sigma-1 (σ1) receptor is a chaperone protein located on the mitochondria-associated membrane of the endoplasmic reticulum, while the sigma-2 receptor (σ2) is an endoplasmic reticulum-resident membrane protein. Recent evidence indicates that both of these receptors figure prominently in the pathophysiology of Alzhe...

journal_title：Neuroscience letters

authors： Jia H,Zhang Y,Huang Y

更新日期：2019-01-19 00:00:00

abstract：:Changes in the activity of gamma-glutamyl transpeptidase (GGTP) and the effects of a subacute dose (150 mg/kg b.wt.) of methionine sulfoximine (MSO) on its activity were studied in cerebral cortex, cerebellum and brainstem of rats of 4 different age groups. GGTP activity increased with increasing age between days 10 a...

journal_title：Neuroscience letters

authors： Rao VL,Murthy CR

更新日期：1991-05-13 00:00:00

abstract：:Neuropeptides orexin-A and -B are related to the regulation of sleep/wakefulness and feeding behaviors. Recently, the peptides have also been shown to yield antinociceptive effects in various pain models. However, it is not clear whether orexins are involved in forms of synaptic plasticity, such as long-term potentiat...

journal_title：Neuroscience letters

authors： Park KB,Weon H

更新日期：2017-11-01 00:00:00

abstract：:Substance P (SP) stimulates striatal dopamine outflow through a cholinergic muscarinic link. SP-induced increase in acetylcholine (Ach) is concentration-dependent, whereas the stimulation of dopamine outflow is seen only over a limited concentration range. M(1) and M(2) receptor stimulation has opposite effects on dop...

journal_title：Neuroscience letters

authors： Khan S,Whelpton R,Michael-Titus AT

更新日期：2000-11-03 00:00:00

abstract：:Afferent baroreceptor information is transmitted to the nucleus tractus solitarius (NTS) in the dorsal medulla where glutamate is thought to be the primary neurotransmitter. However, the subtypes of glutamate receptors involved in the baroreflex remain to be established. The present study compared the distribution of ...

journal_title：Neuroscience letters

authors： Botsford SA,Dean C,Hopp FA,Seagard JL

更新日期：1999-02-12 00:00:00

abstract：:Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results...

journal_title：Neuroscience letters

authors： Lovat PE,Pearson AD,Malcolm A,Redfern CP

更新日期：1993-11-12 00:00:00

abstract：:Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB bindi...

journal_title：Neuroscience letters

authors： Fuji K,Hiramatsu M,Hayashi S,Kameyama T,Nabeshima T

更新日期：1993-02-05 00:00:00

abstract：:To investigate the relationship between apolipoprotein E (APOE) polymorphisms and the severity of traumatic brain injury (TBI) in acute stage in the cohort of mainland Chinese patients. We prospectively identified admissions to the two neurosurgical departments for head injury. A total of 110 subjects with TBI (80 mal...

journal_title：Neuroscience letters

authors： Jiang Y,Sun X,Xia Y,Tang W,Cao Y,Gu Y

更新日期：2006-11-13 00:00:00

abstract：:The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of ampheta...

journal_title：Neuroscience letters

authors： van den Buuse M,van Driel IR,Samuelson LC,Pijnappel M,Martin S

更新日期：2005-01-20 00:00:00

abstract：:Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of ery...

journal_title：Neuroscience letters

authors： Sjölund KF,von Heijne M,Hao JX,Xu XJ,Sollevi A,Wiesenfeld-Hallin Z

更新日期：1998-02-27 00:00:00

abstract：:Curcumin is capable of promoting peripheral nerve regeneration in normal condition. However, it is unclear whether its beneficial effect on nerve regeneration still exists under diabetic mellitus. The present study was designed to investigate such a possibility. Diabetes in rats was developed by a single dose of strep...

journal_title：Neuroscience letters

authors： Ma J,Yu H,Liu J,Chen Y,Wang Q,Xiang L

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to clarify the effect of Chinese propolis on the expression level of neurotrophic factors in dental pulp cells (DPCs). We also investigated that the effects of the conditioned medium (CM) of DPCs stimulated by the propolis against oxidative and endoplasmic reticulum (ER) stresses in human...

journal_title：Neuroscience letters

authors： Kudo D,Inden M,Sekine S,Tamaoki N,Iida K,Naito E,Watanabe K,Kamishina H,Shibata T,Hozumi I

更新日期：2015-03-04 00:00:00