Abstract:
:The recurrence of dopamine-immunoreactive (DAi) fibers and the effect of the adrenocorticotrophic hormone (ACTH)-(4-9) analog ORG 2766 on this process were investigated 1, 4, 12 and 24 weeks after a unilateral 6-hydroxydopamine (6-OHDA) lesion in the nucleus accumbens (NAc). DAi fibers were almost completely absent 1 week after the lesion. A gradual increase in DAi fibers throughout the NAc was observed, with subnormal values at 24 weeks. Treatment with ORG 2766 during the first week after the lesion resulted in more DAi fibers 4 weeks after the lesion as compared to placebo treatment, but not 12 and 24 weeks after the lesion. After 6-OHDA lesioning reinnervation of the NAc takes place and this process is transiently facilitated by ORG 2766.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Vos PE,Steinbusch HW,Van Ree JMdoi
10.1016/0304-3940(96)12498-8subject
Has Abstractpub_date
1996-03-22 00:00:00pages
21-4issue
1eissn
0304-3940issn
1872-7972pii
0304394096124988journal_volume
207pub_type
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