Abstract:
:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited ADs, and following in vitro ethanol withdrawal, the duration of afterdischarges was significantly enhanced (37 +/- 2%, n = 21). Therefore, in vitro ethanol exposure with subsequent withdrawal is associated with an enhancement of NMDA receptor-dependent afterdischarges. These results are consistent with the involvement of NMDA receptors in ethanol withdrawal hyperexcitability.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Morrisett RAdoi
10.1016/0304-3940(94)91055-3subject
Has Abstractpub_date
1994-02-14 00:00:00pages
175-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)91055-3journal_volume
167pub_type
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