Potentiation of N-methyl-D-aspartate receptor-dependent afterdischarges in rat dentate gyrus following in vitro ethanol withdrawal.

Abstract:

:The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited ADs, and following in vitro ethanol withdrawal, the duration of afterdischarges was significantly enhanced (37 +/- 2%, n = 21). Therefore, in vitro ethanol exposure with subsequent withdrawal is associated with an enhancement of NMDA receptor-dependent afterdischarges. These results are consistent with the involvement of NMDA receptors in ethanol withdrawal hyperexcitability.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Morrisett RA

doi

10.1016/0304-3940(94)91055-3

subject

Has Abstract

pub_date

1994-02-14 00:00:00

pages

175-8

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)91055-3

journal_volume

167

pub_type

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