Abstract:
:To investigate whether any specific requirement for extracellular Ca2+ exists in the control synaptic vesicle retrieval, we examined the ability of the divalent cation Ba2+ to substitute for Ca2+ in both vesicle exocytosis and endocytosis. Ba2+ stimulated glutamate release from rat cerebrocortical synaptosomes. Ba2+-evoked release was inhibited by bafilomycin A1, indicating release was via exocytosis of synaptic vesicles. However, Ba2+ did not stimulate vesicle retrieval, monitored by a FM2-10-based retrieval assay. Therefore synaptic vesicle retrieval in central nerve terminals has a specific requirement for extracellular Ca2+ and the Ca2+ receptor for retrieval has a different cation specificity to the Ca2+ receptor for exocytosis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cousin MA,Robinson PJdoi
10.1016/s0304-3940(98)00610-7subject
Has Abstractpub_date
1998-08-28 00:00:00pages
1-4issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00610-7journal_volume
253pub_type
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