Increased levels of mitogen activated protein kinase (MAP-K) detected in the injured adult mouse sciatic nerve.


:Adult mouse sciatic nerves (SNs) with attached dorsal root ganglia (DRG) were analysed for the presence of mitogen activated protein kinase (MAP-K) during normal and regenerative conditions. By immunohistochemistry, MAP-K was found to be present in the normal nerve at low levels in both Schwann cells and DRG nerve cell bodies, with a profoundly increased expression during regeneration. In axonal outgrowth assays, treatment with 2 mM 2-aminopurine (2-AP), a MAP-K antagonist, inhibited the regeneration of axons from the SN as well as from the cultured superior cervical ganglia. The reduced outgrowth was probably not due to toxic effects of the drug since the ganglionic protein synthesis was not inhibited. It is possible that 2-AP interferes with regeneration-related events by inhibition of MAP-K.


Neurosci Lett


Neuroscience letters


Svensson B,Ekström PA,Edström A




Has Abstract


1995-11-10 00:00:00














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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lodge D,Johnston GA

    更新日期:1985-05-23 00:00:00

  • Taste cell formation does not require gustatory and somatosensory innervation.

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

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    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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