Abstract:
:Adult mouse sciatic nerves (SNs) with attached dorsal root ganglia (DRG) were analysed for the presence of mitogen activated protein kinase (MAP-K) during normal and regenerative conditions. By immunohistochemistry, MAP-K was found to be present in the normal nerve at low levels in both Schwann cells and DRG nerve cell bodies, with a profoundly increased expression during regeneration. In axonal outgrowth assays, treatment with 2 mM 2-aminopurine (2-AP), a MAP-K antagonist, inhibited the regeneration of axons from the SN as well as from the cultured superior cervical ganglia. The reduced outgrowth was probably not due to toxic effects of the drug since the ganglionic protein synthesis was not inhibited. It is possible that 2-AP interferes with regeneration-related events by inhibition of MAP-K.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Svensson B,Ekström PA,Edström Adoi
10.1016/0304-3940(95)12066-dsubject
Has Abstractpub_date
1995-11-10 00:00:00pages
33-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(95)12066-Djournal_volume
200pub_type
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