Increased levels of mitogen activated protein kinase (MAP-K) detected in the injured adult mouse sciatic nerve.

Abstract:

:Adult mouse sciatic nerves (SNs) with attached dorsal root ganglia (DRG) were analysed for the presence of mitogen activated protein kinase (MAP-K) during normal and regenerative conditions. By immunohistochemistry, MAP-K was found to be present in the normal nerve at low levels in both Schwann cells and DRG nerve cell bodies, with a profoundly increased expression during regeneration. In axonal outgrowth assays, treatment with 2 mM 2-aminopurine (2-AP), a MAP-K antagonist, inhibited the regeneration of axons from the SN as well as from the cultured superior cervical ganglia. The reduced outgrowth was probably not due to toxic effects of the drug since the ganglionic protein synthesis was not inhibited. It is possible that 2-AP interferes with regeneration-related events by inhibition of MAP-K.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Svensson B,Ekström PA,Edström A

doi

10.1016/0304-3940(95)12066-d

subject

Has Abstract

pub_date

1995-11-10 00:00:00

pages

33-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)12066-D

journal_volume

200

pub_type

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