Abstract:
:The taiep rat is a myelin mutant whose immobility episodes (IEs) can be caused by gripping them by the tail. Electroencephalographic recordings during IEs show a rapid-eye movement sleep-like pattern, similar to narcolepsy-cataplexy in canines. Systemic administration of alpha(2)-adrenoceptor agonists and the alpha(1) antagonist increase gripping-generated IEs. Furthermore, adrenergic alpha(2) antagonists decrease them. Serotonin receptors are also involved in the regulation of IEs, because the 5-HT(1A)-5-HT(1B) serotonin-receptor agonists decrease the IE frequency, as do the postsynaptic-serotonergic 5-HT(2A-2C) agonists. The rats were maintained under standard conditions with a 12:12h light:dark cycle, lights on at 0700, with free access to rodent pellets and tap water. Drugs were freshly prepared using sterile water and administered intraperitoneally at 0800 with the observation lasting 90 min. The IEs were caused by gripping the rat's tail every 5 min. Systemic injection of (-)-quinpirole, R(+)-7-hydroxy-2-(dipropylamino)tetralin (7-OH-DPAT), or trans-(+/-)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol ((+/-) PD 128,907) increased both the frequency and mean duration of the IEs. The IEs produced by (-)-quinpirole were blocked by the previous administration of (-)-sulpiride and those by 7-OH-DPAT were blocked by tiapride. Systemic injection of sulpiride reduced gripping-generated IEs, but not the changes with either tiapride or U-99194, two other antagonists. In canine narcolepsy, systemic administration of D(2)-dopaminergic agonists increases the frequency of cataplexies and decreased them by using (-)-sulpiride similar to the pharmacological profile in taiep cataplexies. Because of this evidence, we proposed taiep rats as an adequate model of this sleep illness and for the evaluation of anticataplexic drugs.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Eguibar JR,Cortés Mdel C,Lara-Lozano Mdoi
10.1016/j.neulet.2010.07.086subject
Has Abstractpub_date
2010-10-15 00:00:00pages
189-92issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(10)01027-Xjournal_volume
483pub_type
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