Abstract：
:A random sample of 60 late-onset Alzheimer's disease (AD) cases from a population-based study were apolipoprotein E (apoE) genotyped and clinically examined with a 3-year interval. The epsilon 4 allele carriers had a significantly lower age of disease onset compared to non-epsilon 4 carriers. However, no significant differences were observed between epsilon 4 allele carries and non-carriers for Mini-Mental State Examination (MMSE) test scores at the first examination, in spite of a longer disease duration in the epsilon 4 allele carriers. After 3 years, MMSE test scores were still not significantly different between epsilon 4 carries and non-carriers but more than twice as many non-carriers had died. All other clinical features were similar between epsilon 4 allele carriers and non-carriers. This study indicates that the epsilon 4 allele is associated with a better prognosis of the disease in late-onset AD but that there are probably factors other than the epsilon 4 allele that are important for the AD phenotype.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Basun H,Grut M,Winblad B,Lannfelt Ldoi
10.1016/0304-3940(94)11107-tsubject
Has Abstractpub_date
1995-01-02 00:00:00pages
32-4issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)11107-Tjournal_volume
183pub_type
杂志文章abstract：:Foxp2(R552H) knock-in (KI) mice carrying a mutation related to human speech-language disorder exhibit impaired ultrasonic vocalization and poor Purkinje cell development. Foxp2 is a forkhead domain-containing transcriptional repressor that associates with its co-repressor CtBP; Foxp2(R552H) displays reduced DNA bindin...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2011.11.022
更新日期：2012-01-11 00:00:00
abstract：:Hippocampal choline acetyltransferase was reduced by 89% in rats two weeks after electrolytic lesion of the septum. The hippocampal concentrations of somatostatin (SOM)-14, SOM-28 and high-molecular-weight SOM were unaltered, suggesting that the activity of hippocampal SOM neurones is not influenced by cholinergic aff...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90363-0
更新日期：1986-01-30 00:00:00
abstract：:The Rose Bengal model in rats is widely used to study brain plasticity, functional recovery and restorative therapies. The present study evaluated temporal profiles of hemorrhage and edema by magnetic resonance imaging (MRI) in rats in relation to sensorimotor impairment after photochemically induced cortical infarct....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.09.043
更新日期：2007-11-27 00:00:00
abstract：:Morphine blocked decremental bar pressing of rats to escape electrical stimulation of aversive midbrain sites. These sites included the dorsal central gray area (DCG), the ventral reticular formation (VRF) and the lateral tegmentum (LT). Naloxone, which had no effect alone, blocked the morphine effects of all three av...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(78)90035-6
更新日期：1978-11-01 00:00:00
abstract：:The learned helplessness (LH) developed after repeat inescapable stress is a well validated animal model of human major depression and is not species specific. c-Fos, the protein product of the protooncogene c-fos, is expressed in neurons under a variety of stressors and could reflect the regional neuronal activation....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.04.011
更新日期：2004-06-17 00:00:00
abstract：:Anterograde labelling following focal injections of Phaseolus vulgaris leucoagglutinin was used to identify the threedimensional cortical distribution of thalamocortical (TC) fibers from the ventrolateral nucleus of the thalamus of the cat. The labelled TC fibers were distributed usually in layers I and III of the mot...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90051-7
更新日期：1989-01-16 00:00:00
abstract：:The cyclic AMP/protein kinase A signaling pathway is thought to be involved in neural differentiation of mesenchymal stem cells. In the present study, we examined the involvement of β-adrenoceptor signaling on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells. Mouse iPS cel...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.07.028
更新日期：2012-09-06 00:00:00
abstract：:Copulation was induced in pairs of Aplysia fasciata by adding to the environment a homogenate of the distal portion of the large hermaphroditic duct. Similar effects were not observed in response to an abdominal ganglion homogenate. The data suggest that the duct may secrete a pheromone initiating copulation in Aplysi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90153-3
更新日期：1985-09-06 00:00:00
abstract：:In the rat the response of suprachiasmatic nucleus neurons to steady retinal illumination at different adaptation luminances was studied. The results confirm that in this nucleus the discharge rate is more commonly increased than suppressed by light. Interval histograms indicate that a complex process underlies the di...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(78)90098-8
更新日期：1978-04-01 00:00:00
abstract：:Local cerebral glucose utilization (LCGU) was measured during spontaneous waking and slow wave sleep (SWS) by an adaptation of the [14C]deoxyglucose method to the free moving cat. In awake animals heterogeneous rates of LCGU were observed throughout the brain with values extending from 8 mumol x 100 g-1 x min-1 for wh...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90235-x
更新日期：1982-09-20 00:00:00
abstract：:Light microscopic autoradiographic localization of specific recognition sites for thyrotropin-releasing hormone (TRH) was determined on thin sections of rat brain using the potent analogue [3H](3-Me-His2)-TRH ([3H]MeTRH). Microdensitometric analysis of the relative optical densities of TRH receptor labelling revealed ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90600-7
更新日期：1985-10-10 00:00:00
abstract：:Functional neuroimaging suggests asymmetries of memory encoding and retrieval in the prefrontal lobes, but different hypotheses have been presented concerning the nature of prefrontal hemispheric specialization. We studied an associative memory task involving pairs of Kanji (Chinese) pictographs and unfamiliar abstrac...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02573-3
更新日期：2002-03-01 00:00:00
abstract：:Acetylcholine (Ach) has been considered a major neurotransmitter in the inner ear efferent nerve endings. A bioassay analysis has shown that the electrical stimulation of the crossed olivocochlear bundle increased the Ach-like activity in the perilymph. Applying in vivo microdialysis techniques and high-performance li...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02165-6
更新日期：2001-10-05 00:00:00
abstract：:Basal and interferon (IFN)-induced levels of (2'-5') oligoadenylate synthetase activity were measured in astrocyte cultures from the mouse cerebral cortex, in neurone-enriched and mixed cerebellar cultures, and in two continuous neural cell lines by a radioimmunoassay procedure. All untreated cultures contained measur...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90293-4
更新日期：1986-04-11 00:00:00
abstract：:It is known that mice homozygous for the retinal degeneration (rd) mutation are able to synchronize their circadian rhythms to light-dark cycles. In the present experiments mice were given a choice of a dark or an illuminated living and nesting area. C3H, CBA and C57 rd/rd mice spent more time in the dark than in the ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)13374-2
更新日期：1997-02-07 00:00:00
abstract：:Neural stem cells (NSCs) have been the focus of an intensive effort to direct their differentiation in vitro towards desired neuronal phenotypes for cell replacement therapies. It is thought that NSCs derived from older embryos have limited neurogenic capacity and are restricted towards an astroglial fate. This idea i...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.12.009
更新日期：2014-01-24 00:00:00
abstract：:A series of experiments were designed to examine the potential induction of apoptosis by nitric oxide (NO) donors on cortical neuronal cell culture. A 24 h exposure of three different NO donors, 3-morpholinosydnonimine, S-nitroso-N-acetyl-penicillamine, and S-nitrosoglutathione, induced apoptosis as indicated by follo...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12532-5
更新日期：1996-04-12 00:00:00
abstract：:Pineal serotonin (5-HT), 5-hydroxyindole-acetic acid (5-HIAA), norepinephrine (NE), epinephrine (E) and adrenal corticosterone, NE and E contents were measured spectrofluorometrically 5, 15, 30 and 60 min after insulin treatment to induce hypoglycemic stress. In the pineal gland, hypoglycemic stress caused dramatic de...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90662-d
更新日期：1991-01-02 00:00:00
abstract：OBJECTIVE:The role of Glial Fibrillic Acidic Protein (GFAP) as a potential biomarker for relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) has been controversially discussed. The aim was to characterize the added value of GFAP levels in the CSF of RRMS and CIS patients in correlation ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.07.050
更新日期：2017-09-14 00:00:00
abstract：:Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.10.042
更新日期：2018-01-01 00:00:00
abstract：:The effects of several Ca2+ channel blockers were evaluated on inhibitory junction potential (IJP) evoked in rat colonic circular muscle by electrical field stimulation (EFS). Glass microelecrodes were used to record membrane potential of smooth muscle cells. IJPs were tetrodotoxin-sensitive (1 microM) and disappeared...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12671-9
更新日期：1996-05-31 00:00:00
abstract：:Horseradish peroxidase (HRP), injected into the rat caudal medulla oblongata, was detected by immunoperoxidase staining in 120 microns frozen sections, allowing examination of both the distribution and morphology of transporting neurons. In the hypothalamus, several groups of HRP-labeled neurons could be distinguished...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90270-0
更新日期：1980-10-02 00:00:00
abstract：:The aim of our experiments was to assess the effect of acutely administered corticosterone on the expression of glucocorticoid receptors (GRs) in the brain of rats with high (HR) and low (LR) levels of anxiety. The rats were divided into groups according to their conditioned fear-induced freezing responses and then we...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.11.012
更新日期：2013-01-15 00:00:00
abstract：:Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.10.057
更新日期：2014-01-13 00:00:00
abstract：:Hippocampal neurogenesis is potentially implicated in etiology of depression and as the final common mechanism underlying antidepressant treatments. However, decreased neurogenesis has not been demonstrated in depressed patients and, in animals, reduced cytogenesis was shown in healthy rats exposed to stressors, but, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.03.035
更新日期：2008-05-16 00:00:00
abstract：:The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of ampheta...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.10.013
更新日期：2005-01-20 00:00:00
abstract：:The present study was carried out to examine whether γ-aminobutyric acid (GABA) receptor mechanisms are involved in the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) using intracerebral microdialysis techniques. Perfusion with the GABA receptor antagonists as well as agonists was perf...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.07.040
更新日期：2016-09-06 00:00:00
abstract：:gamma-Aminobutyric acid-transaminase (GABA-T) plays an important role in the metabolism of GABA, particularly in the neurons or glial cells. The present study was undertaken to determine the alteration of GABA-T expression in the gerbil hippocampus after ischemia-reperfusion. In the sham, GABA-T(+) neurons were scatte...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01541-x
更新日期：2000-11-10 00:00:00
abstract：:To test if nitric oxide (NO) is involved in modulation of neuronal activity after global changes of brain function, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) reactivity in the cerebellar cortex was compared in monkeys maintained under anaesthesia for 24-48 h with others only anaesthetised for pe...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00497-7
更新日期：1997-07-18 00:00:00
abstract：:Generation of free radicals and subsequent lipid peroxidation have been proposed to contribute to delayed tissue damage following traumatic spinal cord injury (SCI). Ubiquinols (reduced coenzyme Q), ascorbate (vitamin C), and alpha-tocopherol (vitamin E) are endogenous antioxidants; decreases in tissue levels of these...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90731-n
更新日期：1990-01-01 00:00:00
