NADPH-diaphorase reactivity is reduced in the molecular layer but increased in the granular layer of primate cerebellum after prolonged anaesthesia.

Abstract:

:To test if nitric oxide (NO) is involved in modulation of neuronal activity after global changes of brain function, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) reactivity in the cerebellar cortex was compared in monkeys maintained under anaesthesia for 24-48 h with others only anaesthetised for perfusion. After prolonged anaesthesia, NADPH-d activity was reduced in the molecular layer, but increased in the granular layer, with the maintenance of a parasagittal patchy organisation of the highly reactive granule cells. Selective labelling of NADPH-d in the infraganglionic plexuses deep to a subset of Purkinje cell somata was lost in the anaesthetised animals. This differential alteration of NADPH-d reactivity suggests that NO may play a role in regulation of neuronal and synaptic activity during anaesthesia.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Yan XX,Garey LJ

doi

10.1016/s0304-3940(97)00497-7

subject

Has Abstract

pub_date

1997-07-18 00:00:00

pages

125-8

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(97)00497-7

journal_volume

230

pub_type

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