Abstract:
:To test if nitric oxide (NO) is involved in modulation of neuronal activity after global changes of brain function, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) reactivity in the cerebellar cortex was compared in monkeys maintained under anaesthesia for 24-48 h with others only anaesthetised for perfusion. After prolonged anaesthesia, NADPH-d activity was reduced in the molecular layer, but increased in the granular layer, with the maintenance of a parasagittal patchy organisation of the highly reactive granule cells. Selective labelling of NADPH-d in the infraganglionic plexuses deep to a subset of Purkinje cell somata was lost in the anaesthetised animals. This differential alteration of NADPH-d reactivity suggests that NO may play a role in regulation of neuronal and synaptic activity during anaesthesia.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yan XX,Garey LJdoi
10.1016/s0304-3940(97)00497-7subject
Has Abstractpub_date
1997-07-18 00:00:00pages
125-8issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00497-7journal_volume
230pub_type
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