Abstract：
:The learned helplessness (LH) developed after repeat inescapable stress is a well validated animal model of human major depression and is not species specific. c-Fos, the protein product of the protooncogene c-fos, is expressed in neurons under a variety of stressors and could reflect the regional neuronal activation. Using the LH paradigm in mice, we examined c-Fos expression in several brain regions related to stress response or major depression. The LH mice showed significantly lower c-Fos-like immunoreactivity (FLI) in the hippocampus dentate gyrus and the lateral septal nucleus, and higher FLI in the hypothalamic paraventricular nucleus compared with the naive mice. Our finding in the mice LH model supported previous studies in rats showing that the lateral septal nucleus and the hypothalamic paraventricular nucleus are important in LH behaviors. We further demonstrated that hippocampus dentate gyrus, a region important for learning and major depression, may also be involved in the LH behaviors. These related brain regions could provide a basis for further exploration of the molecular mechanisms underlying LH behaviors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Huang YH,Cheng CY,Hong CJ,Tsai SJdoi
10.1016/j.neulet.2004.04.011keywords:
subject
Has Abstractpub_date
2004-06-17 00:00:00pages
280-3issue
3eissn
0304-3940issn
1872-7972pii
S0304394004004100journal_volume
363pub_type
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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