Abstract:
:Previous studies using various excitatory amino acid antagonists have shown that synaptic transmission between the auditory nerve and the cochlear nucleus of chickens (nuc. magnocellularis; NM) is mediated by non-N-methyl-D-aspartate (non-NMDA) receptors. In the present study we have attempted to define the subclass of non-NMDA receptor in the NM by examining the effects of various excitatory amino acid agonists on synaptically evoked field potentials in an in vitro preparation of the chicken brain stem. Both quisqualate and DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), whose actions operationally define the quisqualate receptor class, caused variable and weak depression of evoked responses in the NM, as did L-glutamate. Kainic acid, on the other hand, completely blocked postsynaptic responses at micromolar concentrations. We conclude that kainate-preferring non-NMDA receptors play a predominant role in mediating transmission in the NM.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nemeth EF,Jackson H,Parks TNdoi
10.1016/0304-3940(85)90148-xsubject
Has Abstractpub_date
1985-09-06 00:00:00pages
297-301issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(85)90148-Xjournal_volume
59pub_type
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