Evidence for the involvement of kainate receptors in synaptic transmission in the avian cochlear nucleus.

Abstract:

:Previous studies using various excitatory amino acid antagonists have shown that synaptic transmission between the auditory nerve and the cochlear nucleus of chickens (nuc. magnocellularis; NM) is mediated by non-N-methyl-D-aspartate (non-NMDA) receptors. In the present study we have attempted to define the subclass of non-NMDA receptor in the NM by examining the effects of various excitatory amino acid agonists on synaptically evoked field potentials in an in vitro preparation of the chicken brain stem. Both quisqualate and DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), whose actions operationally define the quisqualate receptor class, caused variable and weak depression of evoked responses in the NM, as did L-glutamate. Kainic acid, on the other hand, completely blocked postsynaptic responses at micromolar concentrations. We conclude that kainate-preferring non-NMDA receptors play a predominant role in mediating transmission in the NM.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Nemeth EF,Jackson H,Parks TN

doi

10.1016/0304-3940(85)90148-x

subject

Has Abstract

pub_date

1985-09-06 00:00:00

pages

297-301

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(85)90148-X

journal_volume

59

pub_type

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