Abstract:
:Bleedings in the ganglionic eminence (GE) being a prominent domain of the telencephalic proliferative zone is a frequent complication of preterm infants. Such bleedings may induce cellular responses in the vicinity of the lesion. Using immunohistochemistry, this study demonstrates for the first time that leukemia inhibitory factor (LIF) belonging to the family of neuropoetic cytokines is expressed in GE cells up to 200 microm from the lesion (six brains, gestational age 22-26 weeks); whereas control brains do not exhibit any LIF-immunoreactive cells in the GE. The expression of LIF in cases with bleedings may interfere with normal developmental processes taking place within the ganglionic eminence.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ulfig Ndoi
10.1016/s0304-3940(00)01778-xkeywords:
subject
Has Abstractpub_date
2001-02-16 00:00:00pages
153-5issue
1-2eissn
0304-3940issn
1872-7972pii
S030439400001778Xjournal_volume
299pub_type
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