Abstract：
:Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we investigated this mutation in 95 healthy controls and in 111 sporadic AD cases by polymerase chain reaction-restriction fragment length polymorphism method in order to study this hypothesis in the Japanese AD population. Allelic frequencies with the I1000V polymorphism in the gene were 7.4 and 6.8% in the control and AD groups, respectively. Our results failed to demonstrate an association between this polymorphism and Japanese sporadic AD, and the A2M I1000V mutation does not seem to be a risk factor per se for sporadic AD.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai Hdoi
10.1016/s0304-3940(00)01330-6keywords:
subject
Has Abstractpub_date
2000-08-25 00:00:00pages
154-6issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(00)01330-6journal_volume
290pub_type
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journal_title：Neuroscience letters
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