Abstract:
:Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Surmeier DJ,Bargas J,Kitai STdoi
10.1016/0304-3940(89)90122-5subject
Has Abstractpub_date
1989-09-11 00:00:00pages
331-7issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(89)90122-5journal_volume
103pub_type
杂志文章abstract::The monoamine innervation of the organum vasculosum lamina terminalis (OVLT) was studied using fluorescence histochemistry and the autoradiographic tracing method. Fluorescence histochemistry demonstrates serotonin terminals in close proximity to the capillary plexus of the OVLT, in the same region where the apparent ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(77)90082-9
更新日期:1977-08-01 00:00:00
abstract::The thickness of the dura mater was obtained from ultrasound probes on the skull and fast Fourier transform-Cepstrum through a probability process at various intracranial pressures (ICP), measured with pressure transducers, in 12 anesthetized dogs. There was a constant relationship between changes in thickness (micron...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11949-w
更新日期:1995-09-22 00:00:00
abstract::The extracellular homeostasis of glutamate in the brain is maintained by the efficient uptake into astroglial cells. The high extracellular glutamate levels seen during seizures are therefore probably a result of both an increased synaptic release and a deranged glutamate uptake. In this study we used immuno-blotting ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01284-2
更新日期:2000-08-11 00:00:00
abstract::Hippocampal norepinephrine (NE) is secreted by neurons projecting from the locus coeruleus (LC) to the hippocampus; LC nicotinic receptors (NAchRs) are involved in the effects of systemic nicotine on this pathway. To clarify the NAchR subtypes, NAchR antagonists, termed alpha-conotoxins, were microinjected into the LC...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00293-1
更新日期:1999-05-07 00:00:00
abstract::Much research is focused on developing novel drugs to improve memory. In particular, psychostimulants have been shown to enhance memory and have a long history of safe use in humans. In prior work, we have shown that very low doses of amphetamine administered before training on a Pavlovian fear-conditioning task can d...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.10.049
更新日期:2010-01-01 00:00:00
abstract::The retina and nucleus isthmi both project in laminar fashion to the superficial layers of the frog's tectum. In order to determine whether isthmo-tectal axons show collateral sprouting after retinotectal input is removed, we injected [3H] proline into the nucleus isthmi and measured the volume of the crossed isthmo-t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90252-4
更新日期:1981-12-11 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12555-6
更新日期:1996-04-19 00:00:00
abstract::The effect of K-252a, a new alkaloid-like kinase inhibitor from the culture broth of Nocardiopsis sp., on the action of nerve growth factor on normal nerve cells was examined. Nerve cells were isolated from the dorsal root ganglia of chick embryo by trituration without using digesting enzymes, and were seeded on colla...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90137-1
更新日期:1988-04-22 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90607-6
更新日期:1994-04-25 00:00:00
abstract::2-Deoxy-d-glucose (2DG) is an analog of glucose that is effectively taken up by cells competing with normal glucose but cannot be further utilized to produce energy. It was previously reported that 2DG can mimic the beneficial effects of dietary restriction in experimental models of neurodegenerative disorders and can...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.11.007
更新日期:2009-01-16 00:00:00
abstract::Nitric oxide (NO) from endothelial or neuronal NO synthases (eNOS or nNOS) may contribute both to the cerebrovascular responses to oxygen and potentially to the peroxynitrite-mediated toxic effects of hyperbaric oxygen (HBO(2)) on the central nervous system (CNS O(2) toxicity). In mice lacking eNOS or nNOS (-/-), regi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00432-4
更新日期:2003-06-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(82)90417-7
更新日期:1982-06-30 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.12.034
更新日期:2005-04-22 00:00:00
abstract::A characteristic of Parkinson's disease (PD) is the development of tremor within the 4-6Hz range. One method used to better understand pathological tremor is to compare the responses to tremor-type actions generated intentionally in healthy adults. This study was designed to investigate the similarities and difference...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.11.040
更新日期:2013-02-08 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.02.038
更新日期:2016-04-08 00:00:00
abstract::Basal serotonin (5-HT) release, measured in the presence of imipramine, was significantly reduced in slices of hippocampus, n. accumbens and frontal cortex from rats subjected to forced swim test and chronic isolation. Only in the hippocampus, in the two animal models of depression, K-stimulated release was increased....
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90584-8
更新日期:1993-11-12 00:00:00
abstract::The expression of five muscarinic receptor mRNAs (m1, m2, m3, m4, m5) was examined in neostriatum, hippocampus and frontal cortex of 3, 18, and 33 month old rats. Transcripts for ml (3.0 kb), m2 (6.2 kb), m3 (4.5 kb) and m4 (3.3 kb) were detected in all brain regions studied. A 6.0 kb transcript for the m5 muscarinic ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90022-1
更新日期:1994-06-20 00:00:00
abstract::Various tracer substances were injected into the spinal cord, the dorsal column nuclei, the trigeminal nuclear complex and the somatosensory cortex in Madagascan hedgehog tenrecs. With the exception of the cases injected exclusively into the spinal cord all injections gave rise to sparse, but distinct anterograde proj...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(96)13305-x
更新日期:1997-01-17 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90288-7
更新日期:1994-08-29 00:00:00
abstract:BACKROUND:8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurod...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.09.048
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abstract::Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral ef...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.03.001
更新日期:2019-05-14 00:00:00
abstract::The present study compared performance and event-related brain potentials between dyslexic subjects and control subjects while they performed a spatial selective attention-shifting task. The subjects received a prestimulus cue on each trial, which indicated whether the subjects should attend to a position to the left ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.10.072
更新日期:2005-02-10 00:00:00
abstract::Extracellular concentration of nitrite (NO2-), an oxidized product of nitric oxide (NO), was measured consecutively in the dorsal region of the rat suprachiasmatic nucleus (SCN) by means of in vivo microdialysis. The NO2- concentrations in the dialysates showed robust circadian rhythm under a 12:12 h light/dark cycle ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)01744-x
更新日期:2001-05-11 00:00:00
abstract::Central administration of colchicine causes accumulation of catecholamines in nerve cell bodies and enhances their visualisation in the rat brain by the formaldehyde-glutaraldehyde (FAGLU) histofluorescence method. The detection of catecholamine-containing nerve cells by the FAGLU method was considerably improved in r...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90176-9
更新日期:1984-12-21 00:00:00
abstract::The hypothesis involving glutamate in the neuropathology of schizophrenia has attracted great interest. Several studies report dysfunctions in glutamatergic systems, including alterations in kainate and N-methyl-D-aspartate (NMDA) receptors in various areas, as well as changes in the number of glutamate uptake sites. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)00563-6
更新日期:1997-08-22 00:00:00
abstract::The biological clock of the suprachiasmatic nuclei drives numerous physiological and behavioural circadian rhythms. In this study, we addressed the question as to whether different components of the clock may control separately various circadian functions. Using the rat transpineal microdialysis tool, we analysed the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.11.007
更新日期:2006-03-20 00:00:00
abstract::Transection of the non-glutamatergic septohippocampal fibers 3-5 days prior to intrahippocampal microinjection of 1 microgram kainic acid (KA) or 3 micrograms ibotenic acid (IBO) protect dentate granule cells against KA but not IBO. In the transected animals, a significant reduction of KA-induced behavioral seizures c...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90268-2
更新日期:1980-10-02 00:00:00
abstract::We examined whether the mGluR1 and mGluR5 were involved in development and maintenance of behavioral signs of non-evoked pain and secondary mechanical hyperalgesia induced by knee joint inflammation. Selective mGluR1 antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA: 50, 100, 200 microM/25 microl, n=10 per gro...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.01.063
更新日期:2007-04-12 00:00:00
abstract::The functional contribution of cloned subunits to insect nicotinic acetylcholine (ACh) receptors has been difficult to determine using heterologous expression. Instead, in this study we explore the subunit composition of naturally expressed functional receptors in an insect using RNA interference. The nicotinic alpha ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02228-5
更新日期:2001-11-09 00:00:00
abstract::We assessed whether tolerance develops to the antinociceptive effect of intrathecal (i.t.) orphanin FQ, the endogenous ligand of the orphan opioid-like receptor, and whether there is a cross-tolerance between the antinociceptive effect of i.t. orphanin FQ and the mu opioid receptor agonist morphine. Orphanin FQ admini...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(97)13401-2
更新日期:1997-02-14 00:00:00