Soft-food diet induces oxidative stress in the rat brain.

Abstract:

:Decreased dopamine (DA) release in the hippocampus may be caused by dysfunctional mastication, although the mechanisms involved remain unclear. The present study examined the effects of soft- and hard-food diets on oxidative stress in the brain, and the relationship between these effects and hippocampal DA levels. The present study showed that DA release in the hippocampus was decreased in rats fed a soft-food diet. Electron spin resonance studies using the nitroxyl spin probe 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl directly demonstrated a high level of oxidative stress in the rat brain due to soft-food diet feeding. In addition, we confirmed that DA directly react with reactive oxygen species such as hydroxyl radical and superoxide. These observations suggest that soft-food diet feeding enhances oxidative stress, which leads to oxidation and a decrease in the release of DA in the hippocampus of rats.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Yoshino F,Yoshida A,Hori N,Ono Y,Kimoto K,Onozuka M,Lee MC

doi

10.1016/j.neulet.2011.12.015

subject

Has Abstract

pub_date

2012-02-02 00:00:00

pages

42-6

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(11)01601-6

journal_volume

508

pub_type

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