Abstract：
:Transcranial pulsed current stimulation (tPCS) is a non-invasive brain stimulation technique that employs weak, pulsed current at different frequency ranges, inducing electrical currents that reach cortical and subcortical structures. Very little is known about its effects on brain oscillations and functional connectivity and whether these effects are dependent on the frequency of stimulation. Our aim was to evaluate the effects of tPCS with different frequency ranges in cortical oscillations indexed by high-resolution qEEG changes for power and interhemispheric coherence. Thirty-eight healthy subjects were enrolled and received a single 20-min session of either sham or active stimulation with 1 Hz, 100 Hz or random frequency (1-5 Hz). We conducted an exploratory analysis to detect changes in mean power for theta, alpha and beta, and interhemispheric coherence for alpha and theta and four different sub-bands cognitive and non-specific adverse effects were recorded. We found that active stimulation with a random frequency ranging between 1 and 5 Hz is able to significantly increase functional connectivity for the theta and low-alpha band as compared to sham and active stimulation with either 1 or 100 Hz. Based on these findings, we discuss the possible effects of tPCS on resting functional connectivity for low-frequency bands in fronto-temporal areas. Future studies should be conducted to investigate the potential benefit of these induced changes in pathologic states.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Castillo Saavedra L,Morales-Quezada L,Doruk D,Rozinsky J,Coutinho L,Faria P,Perissinotti I,Wang QM,Fregni Fdoi
10.1016/j.neulet.2014.06.021subject
Has Abstractpub_date
2014-08-08 00:00:00pages
61-5eissn
0304-3940issn
1872-7972pii
S0304-3940(14)00493-5journal_volume
577pub_type
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