Role of the orexinergic system in acute haemorrhage in the rat.

Abstract:

:Orexins (OXs) stimulate sympathetic nerve activity to increase arterial pressure (AP) and heart rate (HR). We have previously reported that the OX(1)-receptor antagonist SB-334867 reversed the sympathomimetic actions of orexin A (OXA). In the present study we have investigated the role(s) of the orexinergic system in sympathetic activation during haemorrhage in rats. Sixteen Wistar rats, anaesthetised with pentobarbital, were assigned to 2 groups: saline i.p. (group S) and SB-334867 30 mg/kg i.p. (group SB) n=8 each. Haemorrhagic shock was established by acute withdrawal of 10 ml/kg of blood via an arterial catheter three times with a 30 min interval between each withdrawal. Haemodynamics were assessed 30 min after 10, 20, and 30 ml/kg of blood withdrawal. In addition, plasma orexin A and catecholamine concentrations in the shed blood were determined. In both groups, mean AP (MAP) and HR decreased significantly. Plasma catecholamine concentrations significantly increased following blood withdrawal. The reduction in MAP/HR and elevation of catecholamine levels were dependent on the total amount of shed blood. There were no differences between the groups. Plasma OXA concentrations increased to a greater extent in group SB than group S in response to haemorrhage. There was a significant correlation between plasma catecholamines and %change in MAP (epinephrine: r=0.553, p=0.0001, norepinephrine: r=0.374, p=0.0087) and HR (epinephrine: r=0.403, p=0.005, norepinephrine: r=0.436, p=0.002). There was no correlation with plasma orexin A levels. These data suggest that despite a weak activation the orexinergic system is unlikely to make a major contribution to the response to haemorrhage.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hirota K,Kushikata T,Yoshida H,Kudo M,Kudo T

doi

10.1016/j.neulet.2007.12.015

subject

Has Abstract

pub_date

2008-02-20 00:00:00

pages

162-6

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(07)01278-5

journal_volume

432

pub_type

杂志文章
  • Experimental hypothyroidism increases immobility in rats in the forced swim paradigm.

    abstract::Effects of severe and mild hypothyroidism on the immobile response to inescapable stress were examined in male Wistar rats using the forced swim paradigm. Rats were exposed to two sessions of inescapable swim stress: pretest (for 15 min) followed by test (for 5 min) 24 h later. Surgically thyroidectomized rats showed ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00664-2

    authors: Kulikov A,Torrésani J,Jeanningros R

    更新日期:1997-10-03 00:00:00

  • Retinal dopamine sensitivity to MPP+ toxicity: electrophysiological and biochemical evaluation.

    abstract::This study concerns the effect of intravitreal injection of 1-methyl-4-phenylpyridinium ion (MPP+) on the electroretinograms (ERG) and on the levels of retinal dopamine (DA) in rabbits. The right eye was injected intravitreously with MPP+ while the other received only the vehicle and served as control. The administrat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90784-2

    authors: Harnois C,Marcotte G,Daigle M,Di Paolo T

    更新日期:1989-12-15 00:00:00

  • Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.

    abstract::Tau in cerebrospinal fluid (CSF) has been proposed as a diagnostic marker for Alzheimer's disease (AD). This paper presents a new sensitive sandwich ELISA allowing quantitation of tau from 8 microl CSF/well. A human specific monoclonal tau antibody HT7 was used as a capture antibody and a mixture of polyclonal tau ant...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.03.022

    authors: Yamamori H,Khatoon S,Grundke-Iqbal I,Blennow K,Ewers M,Hampel H,Iqbal K

    更新日期:2007-05-17 00:00:00

  • Expression of vascular endothelial growth factor mRNA following transient forebrain ischemia in rats.

    abstract::Using a reproducible two-vessel occlusion model for forebrain ischemia in rats, we investigated the temporal and spatial changes of vascular endothelial growth factor (VEGF) expression after transient forebrain ischemia with Northern blot analysis and in situ hybridization. Northern blot analysis revealed that VEGF mR...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00219-0

    authors: Lee MY,Ju WK,Cha JH,Son BC,Chun MH,Kang JK,Park CK

    更新日期:1999-04-16 00:00:00

  • Interaction of local anaesthetic agents with the endogenous norepinephrine transporter in SH-SY5Y human neuroblastoma cells.

    abstract::Use of intravenous guanethidine for the treatment of complex regional pain syndrome type I is of variable efficacy. Guanethidine injection is painful, so local anaesthetic is co-administered. We hypothesize that local anaesthetic inhibits uptake of guanethidine and hence reduces its efficacy. In this study we have exa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)01822-5

    authors: Joyce PI,Atcheson R,Marcus RJ,Heffernan AM,Rowbotham DJ,Lambert DG

    更新日期:2001-06-15 00:00:00

  • Unrelated peptide immunoreactivities coexist in neurons of the rat lateral dorsal hypothalamus: human growth hormone-releasing factor1-37-, salmon melanin-concentrating hormone- and alpha-melanotropin-like substances.

    abstract::Antisera raised against 3 unrelated synthetic neuropeptides - salmon melanin-concentrating hormone, human growth hormone-releasing factor1-37, and alpha-melanotropin - stained the same extensive neuron population in lateral and dorsal areas of the posterior hypothalamus. Controls for specificity have shown that these ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90309-0

    authors: Fellmann D,Bugnon C,Risold PY

    更新日期:1987-03-09 00:00:00

  • Effects of maternal protein malnutrition on oxidative markers in the young rat cortex and cerebellum.

    abstract::Malnutrition affects a large number of children worldwide. Inadequate nutrition during pre- and postnatal period may alter brain development resulting in biochemical, physiological and anatomical changes which in turn could cause behavioral abnormalities. The impairment of the central nervous system following protein ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.07.052

    authors: Bonatto F,Polydoro M,Andrades ME,Conte da Frota ML Jr,Dal-Pizzol F,Rotta LN,Souza DO,Perry ML,Fonseca Moreira JC

    更新日期:2006-10-09 00:00:00

  • Mouse muscle epsilon- and gamma-containing acetylcholine receptors expressed in Xenopus laevis oocytes do not differ in their degradation half-lives.

    abstract::Mouse acetylcholine receptors (AChRs) consisting of either the embryonic form (2 alpha, 1 beta, 1 delta and 1 gamma) or the adult form (2 alpha, 1 beta, 1 delta and 1 epsilon) were expressed in Xenopus laevis oocytes. As expected, the single channel conductance was approximately 52 pS and the exponential decay time co...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90123-6

    authors: Liu E,Hamill OP,Salpeter MM

    更新日期:1994-06-06 00:00:00

  • Low extracellular magnesium ions induce lipid peroxidation and activation of nuclear factor-kappa B in canine cerebral vascular smooth muscle: possible relation to traumatic brain injury and strokes.

    abstract::The present study was designed to test the hypothesis that administration of low extracellular levels of magnesium ions ([Mg(2+)](o)) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, degradation of IkappaB-alpha, and activation of nuclear transcription factor kappa B (NF-kappaB)...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00134-4

    authors: Altura BM,Gebrewold A,Zhang A,Altura BT

    更新日期:2003-05-08 00:00:00

  • Effects of mechanical vibration of the foot sole and ankle tendons on cutaneomuscular responses in man.

    abstract::The modulation of cutaneomuscular responses in response to mechanical vibration applied to the foot sole and to the ankle tendons was established in ten healthy subjects. The effects of mechanical vibration applied to the skin adjacent to the tibialis anterior (TA) and Achilles tendons were examined in two subjects. W...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.04.042

    authors: Smith AC,Mummidisetty CK,Rymer WZ,Knikou M

    更新日期:2013-06-17 00:00:00

  • Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum.

    abstract::Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90122-5

    authors: Surmeier DJ,Bargas J,Kitai ST

    更新日期:1989-09-11 00:00:00

  • Activation of substantia gelatinosa by midbrain reticular stimulation demonstrated with 2-deoxyglucose in the rat spinal cord.

    abstract::The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map the descending effects of midbrain reticular stimulation on the rat cervical spinal cord. The stimulation evoked consistently a defensive 'freezing' reaction as well as a large and highly localized increase in 2-DG uptake in the substantia gelatino...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90283-1

    authors: Gonzalez-Lima F

    更新日期:1986-04-24 00:00:00

  • Modulation of the nicotinic acetylcholine receptor channels by spermine in Xenopus muscle cell culture.

    abstract::The modulation by endogenous polyamine spermine on acetylcholine (ACh)-induced currents was evaluated using a outside-out patch and whole-cell voltage-clamp recordings from cultured Xenopus muscle cells. Spermine potentiated the ACh-induced whole-cell currents at micromolar concentrations but is less effective at mill...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90216-x

    authors: Hsu KS

    更新日期:1994-11-21 00:00:00

  • Proteasomal function is impaired in substantia nigra in Parkinson's disease.

    abstract::The accumulation of alpha-synuclein, ubiquitin and other proteins in Lewy bodies in degenerating dopaminergic neurones in substantia nigra in idiopathic Parkinson's disease (PD) suggest that inhibition of normal/abnormal protein degradation may contribute to neuronal death. We now show for the first time that the chym...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01701-8

    authors: McNaught KS,Jenner P

    更新日期:2001-01-19 00:00:00

  • Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals.

    abstract::DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported undergo oxidation preferentially at the 106th cysteine residue (Cys-106) under oxidative stress. Recently, it has been found that the levels of oxidized DJ-1 in erythrocytes of unmedicated PD patients are markedly higher than th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.08.007

    authors: Akazawa YO,Saito Y,Hamakubo T,Masuo Y,Yoshida Y,Nishio K,Shichiri M,Miyasaka T,Iwanari H,Mochizuki Y,Kodama T,Noguchi N,Niki E

    更新日期:2010-10-15 00:00:00

  • cAMP-dependent and cAMP-independent modulation of synaptic transmission in guinea-pig superior cervical ganglion.

    abstract::RMI 12330A dose-dependently inhibits cAMP accumulation induced by PGE2 in guinea-pig superior cervical ganglion (SCG). Norepinephrine (NE) is unable to modify cAMP concentration in the same preparation. On the other hand, both PGE2 and NE block the firing discharge of guinea-pig SCG neurons elicited by electrical stim...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(82)90274-9

    authors: Borasio PG,Ferretti ME,Biondi C,Trevisani A

    更新日期:1982-10-08 00:00:00

  • Object memory impairment at post-drug Day 15 but not at Day 1 after a regimen of repeated treatment with oral methylphenidate.

    abstract::Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder in children and adults. Its similarity to other psychostimulants suggests that, at certain doses, the drug may generate lasting neuroadaptations that can be detrim...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.03.001

    authors: Taukulis HK,Bigney EE,Fry MD,Hooper C

    更新日期:2014-04-30 00:00:00

  • Chronic ethanol consumption increases the amount of mRNA for retinoic acid and triiodothyronine receptors in mouse brain.

    abstract::It is known that alcohol induces disorders in the metabolism of retinoids and particularly in the biosynthetic pathways of retinoic acid (RA). Since RA has, along with other hormones and particularly triiodothyronine (T3), a physiological role in the adult brain, the effect of chronic exposure to alcohol on RA and T3 ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(96)12455-1

    authors: Alfos S,Higueret P,Pallet V,Higueret D,Garcin H,Jaffard R

    更新日期:1996-03-15 00:00:00

  • Sustained expression of functional nerve growth factor in primary septo-hippocampal cell cultures by liposome-mediated gene transfer.

    abstract::We examined liposome-mediated gene transfection of nerve growth factor (NGF) in primary central nervous system cultures. RT-PCR analyses detected increased expression of NGF mRNA one day after liposome-mediated NGF gene transfection. ELISA studies detected large increases in NGF protein in cells and in culture medium ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90819-2

    authors: Yang K,Faustinella F,Xue JJ,Whitson J,Kampfl A,Mu XS,Zhao X,Taglialatela G,Perez-Polo JR,Clifton G

    更新日期:1994-12-05 00:00:00

  • Organum vasculosum lamina terminalis: innervation by serotonin neurons of the midbrain raphe.

    abstract::The monoamine innervation of the organum vasculosum lamina terminalis (OVLT) was studied using fluorescence histochemistry and the autoradiographic tracing method. Fluorescence histochemistry demonstrates serotonin terminals in close proximity to the capillary plexus of the OVLT, in the same region where the apparent ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(77)90082-9

    authors: Moore RY

    更新日期:1977-08-01 00:00:00

  • Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.

    abstract::beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were tested for their ability to produce acute excitotoxicity in in embryonic chick retina. gamma-Aminobutyric acid (GABA) release and histology were monitored in retina treated with various concentrations of BOAA, BMAA, kainate (KA), N-methyl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90093-1

    authors: Zeevalk GD,Nicklas WJ

    更新日期:1989-07-31 00:00:00

  • Increased expression of metabotropic glutamate receptor subtype 1 on spinothalamic tract neurons following spinal cord injury in the rat.

    abstract::Spinal cord injury (SCI) leads to an increase in metabotropic glutamate receptor subtype 1 (mGluR1) immunoreactivity in the peri-lesion area. The increased expression of mGluR1 parallels the development of thermal hyperalgesia and mechanical allodynia and has been suggested to contribute to the development and mainten...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02551-4

    authors: Mills CD,Hulsebosch CE

    更新日期:2002-02-15 00:00:00

  • Involvement of central noradrenergic pathways in the control of intestinal motility in rats.

    abstract::Small intestinal motility was monitored in conscious rats chronically fitted with intraparietal electrodes, the third and fourth weeks after intraperitoneal administration of saline (controls) or N-(2-chloro-ethyl)-N-ethyl-2-bromobenzylamine (DSP-4, 50 mg/kg), a noradrenergic neurotoxin. Norepinephrine concentrations ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90205-4

    authors: Fargeas MJ,Fioramonti J,Buéno L

    更新日期:1988-08-01 00:00:00

  • Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus.

    abstract::Activity-dependent neuroprotective protein (ADNP) is a highly conserved vasoactive intestinal peptide (VIP) responsive gene that is expressed abundantly in the brain and in the body and is essential for brain formation and embryonic development. Since, VIP exhibits sexual dimorphism in the hypothalamus, the potential ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.09.077

    authors: Furman S,Hill JM,Vulih I,Zaltzman R,Hauser JM,Brenneman DE,Gozes I

    更新日期:2005-01-03 00:00:00

  • REST levels affect the functional expression of voltage dependent calcium channels and the migratory activity in immortalized GnRH neurons.

    abstract::The repressor element-1 silencing transcription factor (REST) has emerged as a key controller of neuronal differentiation and has been shown to play a critical role in the expression of the neuronal phenotype; however, much has still to be learned about its role at specific developmental stages and about the functiona...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.06.050

    authors: Antoniotti S,Ruffinatti FA,Torriano S,Luganini A,D'Alessandro R,Lovisolo D

    更新日期:2016-08-26 00:00:00

  • Evidence for active acetylcholine metabolism in human amniotic epithelial cells: applicable to intracerebral allografting for neurologic disease.

    abstract::Human amniotic epithelial (HAE) cells have been used for allotransplantation in patients with lysosomal storage disease due to lack of expression of HLA antigens. Previously, we have reported the expression of differentiation markers for both neural stem cells, and neuron and glial cells. In the present study, we inve...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00570-3

    authors: Sakuragawa N,Misawa H,Ohsugi K,Kakishita K,Ishii T,Thangavel R,Tohyama J,Elwan M,Yokoyama Y,Okuda O,Arai H,Ogino I,Sato K

    更新日期:1997-08-22 00:00:00

  • Effect of professional expertise and exposure to everyday life decision-making on moral choices.

    abstract::Moral sense is defined as a feeling of fairness or unfairness of an action that knowingly causes harm to people other than the subject. It is crucial in determining human behavior and becomes pivotal in operational environments. Here we assessed whether professional daily life experience in an operational environment ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2017.06.036

    authors: Boccia M,Verde P,Angelino G,Carrozzo P,Vecchi D,Piccardi L,Colangeli S,Cordellieri P,Ferlazzo F,Giannini AM

    更新日期:2017-07-27 00:00:00

  • NADPH-diaphorase reactivity is reduced in the molecular layer but increased in the granular layer of primate cerebellum after prolonged anaesthesia.

    abstract::To test if nitric oxide (NO) is involved in modulation of neuronal activity after global changes of brain function, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) reactivity in the cerebellar cortex was compared in monkeys maintained under anaesthesia for 24-48 h with others only anaesthetised for pe...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00497-7

    authors: Yan XX,Garey LJ

    更新日期:1997-07-18 00:00:00

  • Displaced ganglion cells in carp retina revealed by the horseradish peroxidase technique.

    abstract::Displaced ganglion cells were identified in the carp retina by the retrograde axonal transport of horseradish peroxidase injected into the optic tectum. Cells in the ganglion cell layer were all labelled, while in the amacrine cell layer only 1/4000 cells were labelled. Because of such low population, it is unlikely t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(78)90064-2

    authors: Tachibana M

    更新日期:1978-09-01 00:00:00

  • Chronic resistance training enhances the spinal excitability of the biceps brachii in the non-dominant arm at moderate contraction intensities.

    abstract::The purpose of the study was to assess corticospinal excitability of the biceps brachii in the non-dominant arm of chronic resistance-trained (RT) and non-RT individuals. Seven chronic-RT and six non-RT male participants performed 4 sets of 5s pseudo-randomized contractions of the non-dominant elbow flexors at 25, 50,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.11.009

    authors: Philpott DT,Pearcey GE,Forman D,Power KE,Button DC

    更新日期:2015-01-12 00:00:00