GABAergic modulation of striatal peptide expression in rats and the alterations induced by dopamine antagonist treatment.

Abstract:

:GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression. Following repeated administration of the D-2 antagonists, eticlopride and haloperidol, there was an increase in enkephalin and GAD67 mRNA levels and parallel decrease in that of substance P. These were unaffected by co-administration of gamma-vinyl GABA. The D-1 antagonist, SCH 23390 administered alone or together with gamma-vinyl GABA did not alter peptide or GAD67 mRNA levels. It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Jolkkonen J,Jenner P,Marsden CD

doi

10.1016/0304-3940(94)90537-1

subject

Has Abstract

pub_date

1994-10-24 00:00:00

pages

273-6

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90537-1

journal_volume

180

pub_type

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