Abstract:
:GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression. Following repeated administration of the D-2 antagonists, eticlopride and haloperidol, there was an increase in enkephalin and GAD67 mRNA levels and parallel decrease in that of substance P. These were unaffected by co-administration of gamma-vinyl GABA. The D-1 antagonist, SCH 23390 administered alone or together with gamma-vinyl GABA did not alter peptide or GAD67 mRNA levels. It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jolkkonen J,Jenner P,Marsden CDdoi
10.1016/0304-3940(94)90537-1subject
Has Abstractpub_date
1994-10-24 00:00:00pages
273-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90537-1journal_volume
180pub_type
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