Abstract:
:Morphological changes induced by 30 min of hypoxia (incubation in medium saturated with 95% N2-5% CO2 instead of the normal 95% O2-5% CO2) were investigated in neurons (layers II/III of the parietal cortex) of rat neocortical brain slices. The cells were identified as intact, reversibly or irreversibly injured. As expected, hypoxia decreased the number of intact cells and increased the number of irreversibly injured cells. Pretreatment of slices with diazoxide (300 microM), an agonist of ATP-dependent potassium (KATP) channels completely prevented the morphological damage induced by hypoxia, whereas tolbutamide (300 microM), an antagonist of KATP channels, was ineffective when given alone. However, tolbutamide (300 microM) co-applied with diazoxide (300 microM), partly reversed the neuroprotective effect of this agonist during hypoxia. In conclusion, KATP channels appear to be present on neocortical neurons and their opening counteracts hypoxia-induced cell injury.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Garcia de Arriba S,Franke H,Pissarek M,Nieber K,Illes Pdoi
10.1016/s0304-3940(99)00603-5keywords:
subject
Has Abstractpub_date
1999-09-24 00:00:00pages
13-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00603-5journal_volume
273pub_type
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