Abstract:
:Delivery of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate receptors (AMPARs) to the synapse is a critical factor controlling synaptic strength. It is now established that blockade of synaptic activity increases the surface expression of AMPARs. Factors modulating the delivery, insertion and expression of AMPARs are not completely known. Using immunohistochemical techniques, we first confirmed rapamycin-mediated inhibition of the mammalian target of rapamycin (mTOR) pathway in cortical neuronal culture. We then demonstrated that acute AMPAR activity blockade increased the synaptic expression of GluR2/3 subunits and rapamycin significantly reduced this expression. Our results suggest a role for the mTOR pathway in surface expression of AMPA receptors on cortical neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wang Y,Barbaro MF,Baraban SCdoi
10.1016/j.neulet.2006.03.011subject
Has Abstractpub_date
2006-06-19 00:00:00pages
35-9issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(06)00252-7journal_volume
401pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:
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abstract::Inattention and impulsivity are the two most important indices for evaluations of ADHD. Currently, inattention and impulsivity were evaluated by clinical scales. The intelligent evaluation of the two indices using machine learning remains largely unexplored. This paper aimed to build regression modes for inattention a...
journal_title:Neuroscience letters
pub_type: 杂志文章
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