Abstract:
:To determine whether a trans-synaptic mechanism triggered the effects of reserpine on adrenomedullary mRNAs encoding the norepinephrine transporter and tyrosine hydroxylase, we administered 10 mg/kg reserpine to rats after unilateral splanchnicotomy, and examined their adrenal medullas using quantitative in situ hybridization. Splanchnicotomy did not alter the decrease in norepinephrine transporter mRNA that follows reserpine administration, but diminished the reserpine-induced increase in tyrosine hydroxylase mRNA by almost 80%. Despite the latter effect, reserpine still induced a significant increase in tyrosine hydroxylase mRNA in denervated adrenal medullas, compared to vehicle-treated adrenal medullas. These results show that a trans-synaptic mechanism does not trigger the decrease in adrenomedullary norepinephrine transporter mRNA following reserpine. In addition, an innervation-independent mechanism mediates a portion of the reserpine-induced increase in adrenomedullary tyrosine hydroxylase mRNA.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cubells JF,Baker H,Volpe BT,Smith GP,Das SS,Joh THdoi
10.1016/0304-3940(95)11699-wsubject
Has Abstractpub_date
1995-07-07 00:00:00pages
189-92issue
3eissn
0304-3940issn
1872-7972pii
030439409511699Wjournal_volume
193pub_type
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