Abstract:
:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the granular and molecular layers of lobule X of the cerebellum and in the medial cerebellar nucleus. The granular and molecular layers as well as the medial cerebellar nucleus ipsilateral to TTX treatment contained elevated levels of Fos relative to the same regions contralaterally and when compared to controls receiving equal volume injections of vehicle. The asymmetric changes in neuronal activity as measured by Fos (genetic activity) in lobule X implicate this region of the vestibulocerebellum in recovery from transient vestibular disruption in the intact system.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Saxon DWdoi
10.1016/s0304-3940(02)01426-xkeywords:
subject
Has Abstractpub_date
2003-03-13 00:00:00pages
57-61issue
1eissn
0304-3940issn
1872-7972pii
S030439400201426Xjournal_volume
339pub_type
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