Asymmetric Fos labeling in lobule X of the cerebellum following transtympanic tetrodotoxin (TTX) in the rat.

Abstract:

:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the granular and molecular layers of lobule X of the cerebellum and in the medial cerebellar nucleus. The granular and molecular layers as well as the medial cerebellar nucleus ipsilateral to TTX treatment contained elevated levels of Fos relative to the same regions contralaterally and when compared to controls receiving equal volume injections of vehicle. The asymmetric changes in neuronal activity as measured by Fos (genetic activity) in lobule X implicate this region of the vestibulocerebellum in recovery from transient vestibular disruption in the intact system.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Saxon DW

doi

10.1016/s0304-3940(02)01426-x

keywords:

subject

Has Abstract

pub_date

2003-03-13 00:00:00

pages

57-61

issue

1

eissn

0304-3940

issn

1872-7972

pii

S030439400201426X

journal_volume

339

pub_type

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