Abstract:
:Dopamine-derived 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, released an enormous amount of serotonin in the rat striatum; the concentration of serotonin increased from undetectable level to 2.53 +/- 0.12 and 3.69 +/- 0.01 microM after perfusion of (R)- and (S)salsolinol, respectively. Salsolinols increased extracellular dopamine level, but to a much lesser degree than serotonin. Other naturally occurring isoquinolines with catechol structure released serotonin and dopamine, but salsolinols were the most potent and selective releaser of serotonin. Serotonin release by salsolinols may be involved in some psychiatric symptoms in L-DOPA therapy or alcoholism.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Maruyama W,Nakahara D,Dostert P,Hashiguchi H,Ohta S,Hirobe M,Takahashi A,Nagatsu T,Naoi Mdoi
10.1016/0304-3940(93)90749-bsubject
Has Abstractpub_date
1993-01-12 00:00:00pages
115-8issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90749-Bjournal_volume
149pub_type
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